AICAR（Acadesine） CA...

AICAR（Acadesine） CAS NO.2627-69-2
AICAR（Acadesine） CAS NO.2627-69-2
AICAR（Acadesine） CAS NO.2627-69-2
AICAR（Acadesine） CAS NO.2627-69-2
AICAR（Acadesine） CAS NO.2627-69-2

AICAR（Acadesine） CAS NO.2627-69-2

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20 Gram

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  • Min.Order :20 Gram
  • Purity: 99.00%
  • Payment Terms : L/C,D/A,D/P

Keywords

AICAR（Acadesine） CAS NO.2627-69-2 2627-69-2 C9H14N4O5

Quick Details

  • Appearance:white powder
  • Application:Pharmaceutical intermediates
  • PackAge:as needed
  • ProductionCapacity:500|Kilogram|Month
  • Storage:Keep in dry and cool condition
  • Transportation:by air or sea

Superiority:

AICAR Basic information
adenosine regulating agents
Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR
Mol File: 2627-69-2.mol
AICAR Structure
 
AICAR Chemical Properties
mp  214-215 °C
storage temp.  −20°C
solubility  H2O: >10 mg/mL
form  powder
color  tan
CAS DataBase Reference 2627-69-2(CAS DataBase Reference)
EPA Substance Registry System 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
 
Safety Information
Hazard Codes  Xi,T
Risk Statements  36/37/38-61
Safety Statements  26-36-45-53
WGK Germany  3
MSDS Information
Provider Language
SigmaAldrich English
 
AICAR Usage And Synthesis
adenosine regulating agents Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). 
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties Solid
Usage glucose uptake stimulant; AMPK activator
Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.
 
AICAR Preparation Products And Raw materials

 

Details:

AICAR Basic information
adenosine regulating agents
Product Name: AICAR
Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR
Mol File: 2627-69-2.mol
AICAR Structure
 
AICAR Chemical Properties
mp  214-215 °C
storage temp.  −20°C
solubility  H2O: >10 mg/mL
form  powder
color  tan
CAS DataBase Reference 2627-69-2(CAS DataBase Reference)
EPA Substance Registry System 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
 
Safety Information
Hazard Codes  Xi,T
Risk Statements  36/37/38-61
Safety Statements  26-36-45-53
WGK Germany  3
MSDS Information
Provider Language
SigmaAldrich English
 
AICAR Usage And Synthesis
adenosine regulating agents Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). 
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties Solid
Usage glucose uptake stimulant; AMPK activator
Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.
 
AICAR Preparation Products And Raw materials

 

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