- Min.Order :1 Gram
- Purity: 98%
- Payment Terms : L/C
Keywords
URMC099 URMC 099 URMC-099
Quick Details
- Appearance:Solid powder
- Application:Inhibitor
- PackAge:
- ProductionCapacity:10|Kilogram|Month
- Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- Transportation:
Superiority:
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. MLK3 activation is associated with many of the pathologic hallmarks of HAND and therefore represents a prime target for adjunctive therapy based on small-molecule kinase inhibition. www.bocsci.com/urmc-099-cas-1229582-33-5-item-470828.html
Details:
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. MLK3 activation is associated with many of the pathologic hallmarks of HAND and therefore represents a prime target for adjunctive therapy based on small-molecule kinase inhibition. www.bocsci.com/urmc-099-cas-1229582-33-5-item-470828.html
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