Factory supply high purity Usnic acid

Details:

Product name: Usnic acid

Botanical name: Usnea Diffracta Vain

CAS No.: 125-46-2

Appearance: Yellow crystalline powder

Functions: 

1. Antibacterial effect

Usnic acid exhibits a broad range of biological activity, indeed it is easier to list the bioassays in which it does not exhibit activity. More often than not, potency is low and of limited value. Usnic acid is an important metabolite for dereplication in discovery research programs.

2. Antiviral effect

Studies have shown that usnic acid has the potential to inhibit the proliferation of mouse polyoma virus. It mainly inhibits the formation of messenger RNA, thereby indirectly inhibiting DNA replication.

3. Insecticidal effect: (+)-usnic acid has the activity of killing the promastigotes of Leishmania donovani (black fever pathogen), and the in vitro active concentration of (+)-usnic acid is 25μg/mL. The minimum effective concentration of S-(-) usnic acid for killing trichomoniasis in vitro is 0.4mg/mL, and there is no significant difference between usnic acid at 0.4mg/mL and above and the same concentration of metronidazole in vitro Chemicalbook trichomoniasis. . Usnic acid has a growth inhibitory effect on trypanosome larvae within 5-30μg/mL. Usnic acid can also significantly reduce the amount of trypanosomes in the blood. Use 40 or 80μg/mL usnic acid to affect infected giants. Phage can cause the disintegration of trypanosomal mitochondria and Golgi apparatus, and the cytoplasm is in a vacuole state, but it does not affect the host cell.

4. Anti-tumor effect: Usnic acid is resistant to wild-type P53 breast cancer cell line MCF7, non-functional P53 breast cancer cell line MDA-MB-231, lung cancer cell line H1299 and various cancer cell Chemicalbook lines L1210, 3LL, DU145 , MCF7, K-562 and U251 are active, but do not cause damage to the DNA of normal cells, so it is expected to be developed into a new generation of anti-cancer drugs.