Erlotinib hydrochloride

Product information

Erlotinib hydrochloride is a kind of small molecule epidermal growth factor receptor tyrosine kinase reversible inhibitors. It is mainly used for the second-line or third-line treatment of the locally advanced or metastatic non-small cell lung cancer and for the treatment of pancreatic cancer.

 Basic information

Antineoplastic drug Erlotinib Application

Product Name:	Erlotinib hydrochloride
Synonyms:	ERLOTINIB HCL;ERLOTINIB HCL SALT;ERLOTINIB HCL SALT :TARCEVA;Erlotinib, Hydrochloride Salt;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva;N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine;[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine;Tarceva HydrochlorideSee E625000
CAS:	183319-69-9
MF:	C22H24ClN3O4
MW:	429.9
EINECS:
Product Categories:	API;Molecular Targeted Antineoplastic;Heterocyclic Compounds;anti-neoplastic;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Tarceva;Antineoplastic;Anti-cancer&immunity;Inhibitors
Mol File:	183319-69-9.mol

 

Chemical Properties

mp	223-225°C
storage temp.	-20°C Freezer
CAS DataBase Reference	183319-69-9(CAS DataBase Reference)

Usage And Synthesis

Application	1. Erlotinib hydrochloride is a kind of small molecule epidermal growth factor receptor tyrosine kinase reversible inhibitor. It is mainly used for the second-line or third-line treatment of locally advanced or metastatic non-small cell lung cancer and for the treatment of pancreatic cancer. 2. HER-1/EGFR tyrosine kinase inhibitors.
Chemical Properties	Off-White Solid
Usage	Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic
Usage	Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM.
Usage	Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.

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