Bardoxolone methyl

Bardoxolone methyl

Bardoxolone methyl

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1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: 98%

Keywords

RTA402 CDDO CDDO Methyl

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CAS NO. 218600-53-4 structure
Product Name NSC713200
Synonyms RTA402;NSC 713200;RTA 402;CDDO Methyl ester;Bardoxolone methyl
Formula C32H43NO4
Molecular Weight 505.69
Spec / Purity 98%
Supply Capacity can supply g scale
Product Description Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.
Details Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon- in mouse macrophages with IC50 of 0.1 nM. [1] Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis.Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke.
 

 

Details:

CAS NO. 218600-53-4 structure
Product Name NSC713200
Synonyms RTA402;NSC 713200;RTA 402;CDDO Methyl ester;Bardoxolone methyl
Formula C32H43NO4
Molecular Weight 505.69
Spec / Purity 98%
Supply Capacity can supply g scale
Product Description Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.
Details Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon- in mouse macrophages with IC50 of 0.1 nM. [1] Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis.Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke.
 

 

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