Topiramate

Product information

 

Topiramate Basic information

Product Name:	Topiramate
Synonyms:	2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranossulfamate;MCN 4853;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-36-D-FRUCTO-PYRANOSE SULFAMATE;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-B-D-FUCTO-PYRANOSE SULFAMATE;2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose sulfamate;2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-BETA-D-FUCTOPYRANOSE SULFAMATE;RWJ 17021;RWJ-17021-000
CAS:	97240-79-4
MF:	C12H21NO8S
MW:	339.36
EINECS:	200-659-6
Product Categories:	Active Pharmaceutical Ingredients;APIs;Health & Beauty;Carbohydrates & Derivatives;Pharmaceuticals;Glutamate receptor;Intermediates & Fine Chemicals;API;TOPAMAX;Pharmaceutical raw materials
Mol File:	97240-79-4.mol

Topiramate Chemical Properties

mp	125°C
storage temp.	2-8°C
solubility	DMSO: ~44 mg/mL
form	solid
color	white

Safety Information

Hazard Codes	Xi,T,F
Risk Statements	36/37/38-39/23/24/25-23/24/25-11
Safety Statements	26-36-45-36/37-16-7
WGK Germany	3
RTECS	LS7083000
Hazardous Substances Data	97240-79-4(Hazardous Substances Data)

MSDS Information

Provider	Language
RWJ-17021	English
SigmaAldrich	English

Topiramate Usage And Synthesis

Chemical Properties	White-to-Off-White Crystalline Powder
Usage	anticonvulsant, antimigraine, GABA-A agonist, AMP/kinate glutamate receptor antagonist, carbonic anhydrase inhibitor
Usage	Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia is indicated for the treat
Usage	Used as an anticonvulsant
Biological Activity	Anticonvulsant. Antagonizes GluR5 kainate receptors (IC 50 = 0.46 μ M), acts as a positive allosteric modulator of GABA A receptor-mediated currents, inhibits Na v channels (IC 50 = 48.9 μ M) and inhibits L-type Ca 2+ channels. Also inhibits carbonic anhydrase (CA) (K i values are 0.1 and 0.2 μ M at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

 

 

 Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

  Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.

    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.

    We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

    We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.