920-66-1 C3H2F6O ...

920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol
920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol

920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol

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920-66-1 C3H2F6O 1,1,1,3,3,3-Hexafluoro-2-propanol 920-66-1 C3H2F6O

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1,1,1,3,3,3-Hexafluoro-2-propanol Basic information
Description Clinical application
Product Name: 1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms: 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL, 99.8+ %;Hexafluoroisopropanol, 99.5%;1,1,1,3,3,3-Hexafluoro-2-propanol, 10% in dichloromethane, for peptide synthesis;1,1,1,3,3,3-Hexafluoro-2-propanol, for peptide synthesis, 99.8%;1,1,1,3,3,3-Hexafluoro-2-propanol, for spectroscopy, 99.9%;1,1,1,3,3,3-Hexafluoro-2-propanol, pure, 99.5+%;1,1,1,3,3,3-Hexafluoro-2-propanolhighpuritygrade;HexafluoroisopropanolD2>99%
CAS: 920-66-1
MF: C3H2F6O
MW: 168.04
EINECS: 213-059-4
Product Categories: Fluoro-Aliphatics;Organics;organofluorine compounds;Organic Fluorides;Fluoro series;1,2,4-Triazole,Triazoles;-;Alcohols;Building Blocks;C2 to C6;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Acylation Reagent
Mol File: 920-66-1.mol
1,1,1,3,3,3-Hexafluoro-2-propanol Structure
 
1,1,1,3,3,3-Hexafluoro-2-propanol Chemical Properties
Melting point −4 °C(lit.)
Boiling point 59 °C(lit.)
density 1.596 g/mL at 25 °C(lit.)
vapor pressure 269 hPa (30 °C)
refractive index n20/D 1.275(lit.)
Fp 4,4°C
storage temp. Store at RT.
form Solid
pka pK1:9.42 (25°C)
Specific Gravity 1.596
color White to yellow
PH 3-4 (H2O)Aqueous solution
Water Solubility 1000 g/L (25 ºC)
λmax 229nm(lit.)
BRN 1841007
Stability: Stable. Incompatible with strong acids, strong bases, alkali metals.
InChIKey BYEAHWXPCBROCE-UHFFFAOYSA-N
CAS DataBase Reference 920-66-1(CAS DataBase Reference)
NIST Chemistry Reference 2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Substance Registry System 2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
 
Safety Information
Hazard Codes C,Xi
Risk Statements 20/22-34
Safety Statements 26-36/37/39-45-27
RIDADR UN 2922 8/PG 2
WGK Germany 2
RTECS UB6450000
F  27
Hazard Note Corrosive
TSCA T
HazardClass 8
PackingGroup II
HS Code 29055910
Toxicity LD50 orally in Rabbit: 1500 mg/kg
MSDS Information
Provider Language
1,1,1,3,3,3-Hexafluoro-2-propanol English
ACROS English
SigmaAldrich English
ALFA English
 
1,1,1,3,3,3-Hexafluoro-2-propanol Usage And Synthesis
Description Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample. HFIP has a certain viscosity, but its boiling point is very low, so we need to analyst under the conditions of 40 ° C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent that results in a non-linearity of the calibration curve obtained from the mixed column bed column. Therefore, Agilent has developed a special column-PL HFIPgel column for this solvent, which has a porous structure that is not affected by solvents.
Clinical application Hexafluoroisopropanol(1,1,1,3,3,3-Hexafluoro-2-propanol) can be used to prepare a variety of high-end chemicals such as fluorosurfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals, and used as a solvent or cleaning agent for electronics industry.
The drug can be used as a fluorinated solvent to increase the efficiency of the reaction of rhodium (I)-catalyzed [4 + 2] intramolecular addition reaction of ether bound alkynyl diene and the [5 + 2] cycloaddition of alkynyl vinyl cyclopropane. The drug is a liquid peptide chemical solvent, a highly soluble solvent for peptide and peptide intermediates. The drug can be used for the analysis of multiple polymers.
Chemical Properties 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.
Chemical Properties Colorless liquid
Uses Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.
Uses 1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.
Uses It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.
Uses Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.
Definition ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.
Air & Water Reactions Water soluble.
Reactivity Profile 1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.
Fire Hazard 1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.
Potential Exposure A specialty solvent for some poly mers; a lavatory reagent.
First aid Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respira tion with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin con tact, avoid spreading material on unaffected skin. Keep vic tim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Shipping UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.
Purification Methods Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.
Incompatibilities HFIP is incompatible with acids, acid chlorides, and oxidizing agents.
Waste Disposal May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.
 
1,1,1,3,3,3-Hexafluoro-2-propanol Preparation Products And Raw materials
Raw materials Cyanogen bromide
Preparation Products Sevoflurane

 

Details:

1,1,1,3,3,3-Hexafluoro-2-propanol Basic information
Description Clinical application
Product Name: 1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms: 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL, 99.8+ %;Hexafluoroisopropanol, 99.5%;1,1,1,3,3,3-Hexafluoro-2-propanol, 10% in dichloromethane, for peptide synthesis;1,1,1,3,3,3-Hexafluoro-2-propanol, for peptide synthesis, 99.8%;1,1,1,3,3,3-Hexafluoro-2-propanol, for spectroscopy, 99.9%;1,1,1,3,3,3-Hexafluoro-2-propanol, pure, 99.5+%;1,1,1,3,3,3-Hexafluoro-2-propanolhighpuritygrade;HexafluoroisopropanolD2>99%
CAS: 920-66-1
MF: C3H2F6O
MW: 168.04
EINECS: 213-059-4
Product Categories: Fluoro-Aliphatics;Organics;organofluorine compounds;Organic Fluorides;Fluoro series;1,2,4-Triazole,Triazoles;-;Alcohols;Building Blocks;C2 to C6;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Acylation Reagent
Mol File: 920-66-1.mol
1,1,1,3,3,3-Hexafluoro-2-propanol Structure
 
1,1,1,3,3,3-Hexafluoro-2-propanol Chemical Properties
Melting point −4 °C(lit.)
Boiling point 59 °C(lit.)
density 1.596 g/mL at 25 °C(lit.)
vapor pressure 269 hPa (30 °C)
refractive index n20/D 1.275(lit.)
Fp 4,4°C
storage temp. Store at RT.
form Solid
pka pK1:9.42 (25°C)
Specific Gravity 1.596
color White to yellow
PH 3-4 (H2O)Aqueous solution
Water Solubility 1000 g/L (25 ºC)
λmax 229nm(lit.)
BRN 1841007
Stability: Stable. Incompatible with strong acids, strong bases, alkali metals.
InChIKey BYEAHWXPCBROCE-UHFFFAOYSA-N
CAS DataBase Reference 920-66-1(CAS DataBase Reference)
NIST Chemistry Reference 2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Substance Registry System 2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
 
Safety Information
Hazard Codes C,Xi
Risk Statements 20/22-34
Safety Statements 26-36/37/39-45-27
RIDADR UN 2922 8/PG 2
WGK Germany 2
RTECS UB6450000
F  27
Hazard Note Corrosive
TSCA T
HazardClass 8
PackingGroup II
HS Code 29055910
Toxicity LD50 orally in Rabbit: 1500 mg/kg
MSDS Information
Provider Language
1,1,1,3,3,3-Hexafluoro-2-propanol English
ACROS English
SigmaAldrich English
ALFA English
 
1,1,1,3,3,3-Hexafluoro-2-propanol Usage And Synthesis
Description Hexafluoroisopropanol (HFIP) is a viscous and colorless liquid with scary odorless. It is an ideal solvent for dissolving polyamides and esters, and it can be used to analyze nylon. Typically, a small amount of sodium trifluoroacetate can be added to the eluent to reduce the aggregation of the sample. HFIP has a certain viscosity, but its boiling point is very low, so we need to analyst under the conditions of 40 ° C to reduce the back pressure of the column. Hexafluoroisopropanol is also a highly polar solvent that results in a non-linearity of the calibration curve obtained from the mixed column bed column. Therefore, Agilent has developed a special column-PL HFIPgel column for this solvent, which has a porous structure that is not affected by solvents.
Clinical application Hexafluoroisopropanol(1,1,1,3,3,3-Hexafluoro-2-propanol) can be used to prepare a variety of high-end chemicals such as fluorosurfactants, fluorine-containing emulsifiers, fluorine-containing pharmaceuticals, and used as a solvent or cleaning agent for electronics industry.
The drug can be used as a fluorinated solvent to increase the efficiency of the reaction of rhodium (I)-catalyzed [4 + 2] intramolecular addition reaction of ether bound alkynyl diene and the [5 + 2] cycloaddition of alkynyl vinyl cyclopropane. The drug is a liquid peptide chemical solvent, a highly soluble solvent for peptide and peptide intermediates. The drug can be used for the analysis of multiple polymers.
Chemical Properties 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.
Chemical Properties Colorless liquid
Uses Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.
Uses 1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.
Uses It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.
Uses Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.
Definition ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.
Air & Water Reactions Water soluble.
Reactivity Profile 1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.
Fire Hazard 1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.
Potential Exposure A specialty solvent for some poly mers; a lavatory reagent.
First aid Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respira tion with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin con tact, avoid spreading material on unaffected skin. Keep vic tim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Shipping UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.
Purification Methods Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.
Incompatibilities HFIP is incompatible with acids, acid chlorides, and oxidizing agents.
Waste Disposal May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.
 
1,1,1,3,3,3-Hexafluoro-2-propanol Preparation Products And Raw materials
Raw materials Cyanogen bromide
Preparation Products Sevoflurane
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