107724-20-9 107724-20-9 107724-20-9
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Eplerenone Basic information |
Product Name: | Eplerenone |
Synonyms: | (7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER;EPLERENONE;EPLERINONE;pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;EPLERENONE 98%;EPLERENONE USP STANDARD;Elperenone;EplerenoneC24H3006 |
CAS: | 107724-20-9 |
MF: | C24H30O6 |
MW: | 414.49 |
EINECS: | |
Product Categories: | Antihypertensive;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;Inspra;Cardiovascular APIs |
Mol File: | 107724-20-9.mol |
Eplerenone Chemical Properties |
mp | 241-243°C |
storage temp. | Store at RT |
Safety Information |
Hazardous Substances Data | 107724-20-9(Hazardous Substances Data) |
Eplerenone Usage And Synthesis |
Chemical Properties | White Solid |
Usage | Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure. |
Usage | Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. It is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it may be more specific for the mineralocorticoid receptor and is sp |
Usage | anticancer agent |
Biological Activity | Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo . |
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