80474-14-2 80474-14-2 80474-14-2
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Product Name: | Fluticasone propionate |
Synonyms: | s-fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate;-17-(1-oxopropoxy)-,s-(fluoromethyl)ester,(6-alpha,11-beta,16-alpha,17-alph;androsta-1,4-diene-17-carbothioicacid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo;cci18781;fluticasone17-propionate;flutide;(6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER;(6 ALPHA,11 BETA,16 ALPHA,17 ALPHA)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER |
CAS: | 80474-14-2 |
MF: | C25H31F3O5S |
MW: | 500.57 |
EINECS: | |
Product Categories: | Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Fluticasone;Steroid and Hormone;HIVID;Hormone Drugs |
Mol File: | 80474-14-2.mol |
Fluticasone propionate Chemical Properties |
mp | 275 °C |
refractive index | 31 ° (C=1, Dioxane) |
storage temp. | Store at RT |
solubility | DMSO: ≥10 mg/mL |
form | solid |
color | white |
Merck | 4211 |
CAS DataBase Reference | 80474-14-2(CAS DataBase Reference) |
Safety Information |
Safety Statements | 22-24/25 |
WGK Germany | 2 |
RTECS | BV7980000 |
MSDS Information |
Provider | Language |
---|---|
Fluticasone propionate | English |
SigmaAldrich | English |
Fluticasone propionate Usage And Synthesis |
Chemical Properties | Crystalline Solid |
Usage | An antiallergic and anti inflammatory |
Usage | A derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory. |
Usage | antiviral |
Usage | Atorvastatin Intermediate |
Usage | A high-affinity, selective glucocorticoid receptor agonist |
Biological Activity | High affinity, selective glucocorticoid receptor agonist (K d = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC 50 = 3.7 nM) in vitro . Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic, clinically-used anti-inflammatory agent with low oral bioavailability. |
Fluticasone propionate Preparation Products And Raw materials |
Raw materials | Dimethyl sulfide-->3-METHOXYPROPIONIC ACID-->Bromofluoromethane |
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