Sofosbuvir intermediate 3

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 1000.0000

1 Kilogram

FOB Price: USD 1000.0000

Min.Order :1 Kilogram
Purity: 98%
Payment Terms : T/T

Keywords

863329-66-2 factory 863329-66-2 Supplier 2'-deoxy-2'-fluoro-2'-C-methyluridine;(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine;PSI-6206;RO 2433;Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-;Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206;2

Quick Details

Appearance:off white powder
Application:Sofosbuvir intermediate 3
PackAge:100g,500g,1kg,25kg
ProductionCapacity:100|Kilogram|Month
Storage:Dry seal
Transportation:Dry seal

Superiority:

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.

We are committed to provide excellence in researching, manufacturing and drug discovery process.

Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.

Details:

PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
IC50 Value: N/A
Target: HCV
PSI-6206 is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. The monophosphate form of PSI-6206 was shown to be metabolized in primary human hepatocytes to its triphosphate analog PSI-7409. Furthermore, the phosphoramidate prodrug of PSI-6206 monophosphate, PSI-7851, was developed. Alternatively, PSI-6130, an aminated analog of PSI-6206 monophosphate, was also developed. PSI-7409, the triphosphate of PSI-6206 inhibits wild-type and S282T HCV RdRp with Ki values of 0.42 and 22 uM, respectively. PSI-7851, the phosphoramidate of PSI-6206 monophosphate, showed an EC50 value of 1.62 uM for inhibiting HCV RNA replication.

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