High Qualiy Norfloxacin

Min.Order / FOB Price:Get Latest Price

25 Kilogram	Negotiable

25 Kilogram

Negotiable

Min.Order :25 Kilogram
Purity: 99% Min
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Norfloxacin supplier 70458-96-7 supplier NORFLOXACIN LACTATE

Quick Details

Appearance:Off-white to light yellow cryst powder
Application:API
PackAge:25 kgs/drum
ProductionCapacity:1|Metric Ton|Month
Storage:Protected from light, stored hermetically and in a dry place
Transportation:By sea or by air

Superiority:

HENAN SUNLAKE ENTERPRISE CORPORATION

Our company advantages:

1、The highest quality with the competitive price.

2、Professional human services.

3、The fastest and safest delivery service.

4、The faster and safest delivery service.

5、The high purity products.

6、We have a sufficient supply of stock.

7、A variety of payments, such as L/C, TT, , MoneyGram or other payments.

Company Information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details:

Norfloxacin Basic information

Anti-infection drug Chemical Properties Application Production method Category Toxicity grading Acute toxicity Flammability and hazardous characteristics Storage Characteristics Extinguishing agent

Product Name:	Norfloxacin
Synonyms:	1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylica;1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylica;am-715;MK-366;NORFLOXACINE;NORFLOXACIN LACTATE;NORFLOXACIN;noroxin
CAS:	70458-96-7
MF:	C16H18FN3O3
MW:	319.33
EINECS:	274-614-4
Product Categories:	Pharmaceutical;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Aromatics;Heterocycles;Pharmaceutical intermediates;NOROXIN
Mol File:	70458-96-7.mol

Norfloxacin Chemical Properties

mp	220°C
storage temp.	2-8°C
CAS DataBase Reference	70458-96-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-37/39
WGK Germany	2
RTECS	VB2005000
HazardClass	IRRITANT

Norfloxacin Usage And Synthesis

Anti-infection drug	Norfloxacin is a quinolone-class anti-infective drug with high degree of antibacterial activity against Escherichia coli, Shigella, Salmonella, Proteus, Pseudomonas aeruginosa and other gram-negative bacteria as well as excellent antibacterial effect against Staphylococcus aureus, pneumococcus bacteria and other Gram-positive bacteria. Its major site of action is in the bacterial DNA gyrase, causing the rapid cracking of the bacteria DNA helix and rapidly inhibiting the bacterial growth and reproduction, finally killing the bacteria. Moreover, it has a strong penetration capability into the cell walls so that it has a stronger bactericidal effect with a small stimulation on the gastric mucosa. It is clinically used for treating the susceptible strains caused infection diseases in urinary tract, intestinal, ENT, gynecology, surgery and dermatology with the major indications as follows: 1, genitourinary infections: simple and complicated urinary tract infections, bacterial prostatitis, gonococcal urinary tract infections and reproductive tract infections. 2, gastrointestinal tract infections. 3, typhoid and other Salmonella infections. Norfloxacin is a concentration-dependent drug which means that the in vivo concentration of the drug is directly proportional to the in vivo efficacy of the drug. The higher the concentration is, the better effect is. As the food will slow down the absorption rate of norfloxacin in the human body, the plasma concentration in the case of taking it before meals (with empty stomach) is 2-3 fold of that in the case of taking it after a meal; therefore, taking it after the meal will greatly reduce the efficacy and may also lead to the drug resistance issue of the susceptible bacteria to the norfloxacin and other similar antimicrobial drugs. The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties	It is white to light yellow crystalline powder. It is odorless with slightly bitter taste. Upon exposure to the air, it can easily absorb moisture to form a hemihydrate. Its color will be deepened upon light. Solubility (mg / m1) in 25 ℃: 0.28 in water, 0.98 in methanol, 1.9 in ethanol, 5.1 in acetone, 5.5 in chloroform, 0.01 in diethyl ether, 0.15 in benzene, 0.94 in ethyl acetate, 5.1 in octanol, and 340 in glacial acetic acid. It is easily soluble in acidic or alkaline solution and slightly soluble in dimethylformamide. Its solubility in the water depends on the pH value and increases rapidly within the range of at pH <5 or pH> 10. It has a melting point of 218-224 ℃. It has also been reported of a melting point of 220-221 ℃. The maximum UV absorption (0.1mol / L sodium hydroxide solution): about 274,325.336nm (A has a height of about 1109, 437, 425). pKal 6.34; pKa2 8.75. Acute toxicity LD50 in mice, rats (mg / kg): All> 4000 oral administration; all hypodermic 1500; 470,> 500 intramuscular injection; 220,270 intravenous injection.
Application	Norfloxacin belongs to third-generation quinolone antibacterial agent developed by Japanese Kyorin Company in 1978. It has features of broad antibacterial spectrum and strong antibacterial activity. It has a strong antibacterial effect against Escherichia coli, pneumobacillus, Aerobacter aerogenes, and Aerobacter cloacae, Proteus, Salmonella, Shigella, Citrobacter and Serratia. It is clinically used for treating the susceptible strain’s causing infections of urinary system, intestinal, respiratory system, surgery, gynecology, ENT and dermatology. It can also be used for the treatment of gonorrhea.
Production method	Nitration of o-dichlorobenzene or the chlorination of nitro chlorobenzene can both generate 3, 4-dichloro-nitrobenzene. It then undergoes reflux with potassium fluoride in dimethyl sulfoxide for being fluorinated to give 3-chloro-4-fluoro-nitrobenzene. In the presence of hydrochloric acid or aqueous acetic acid, it is further reduced by iron to 3-chloro-4-fluoro-aniline. 3-chloro-4-fluoro-aniline was then subject to reflux together with triethyl orthoformate and diethyl malonate (generate diethyl ethoxymethylenemalonate) in the presence of ammonium nitrate to give the condensation product with heating and cyclization in diphenyl ether or liquid paraffin to form the 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate with ethylation and further hydrolyzation to obtain the ethylated product. Finally, the ethylated product is condensed with piperazine to obtain norfloxacin. Its technology is relatively mature with a relative high yield being generally 40% to 65%. However, when introducing the piperazinyl group to the 7 position, the byproduct with the fluorine atom in 6 position can account for about 25%. It is hard for separation that can affect the yield. The overall yield calculated based on nitro chlorobenzene is above 8%. Before the introduction of the pyrazine ring, 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-8-carboxylic acid ethyl ester should first react with fluoroboric acid or a boron trifluoride-diethyl ether or boron acetate to have the carbonyl group in 4 position form boron chelate. Further re-introduction of pyrazinyl can reduce the side reactions of the displacement of the position 7’s fluorine and can increase the yield by 15%, as well as improve the quality of the product. There are many studies regarding the synthesis of norfloxacin at home and abroad. But there have not been too many way for being used in industrial production. The improvement of its synthesis route can be mainly reflected in two aspects. First, improve the process of forming a ring; the second is doing sth on the introduction of piperazine group.
Category	toxic substances
Toxicity grading	poisoning
Acute toxicity	intravenous - rat LD50: 245 mg / kg; Oral - Mouse LD50: 4000 mg / kg
Flammability and hazardous characteristics	it is combustible with combustion produces toxic fumes of nitrogen oxides and fluorides; Side effect when patients take it: musculoskeletal functional changes
Storage Characteristics	ventilation low-temperature and dry
Extinguishing agent	Dry powder, foam, sand, carbon dioxide, water spray
Chemical Properties	Off-white to light yellow cryst powder
Usage	An antibacterial. Fluorinated quinolone antibacterial
Usage	Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.