High Qualiy Metronidazole

Min.Order / FOB Price:Get Latest Price

25 Kilogram	Negotiable

25 Kilogram

Negotiable

Min.Order :25 Kilogram
Purity: 99% Min
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Metronidazole supplier 443-48-1 supplier 1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole

Quick Details

Appearance:white to yellow crystal solid
Application:API
PackAge:25 kgs/drum
ProductionCapacity:1|Metric Ton|Month
Storage:Protected from light, stored hermetically and in a dry place
Transportation:By sea or by air

Superiority:

HENAN SUNLAKE ENTERPRISE CORPORATION

Our company advantages:

1、The highest quality with the competitive price.

2、Professional human services.

3、The fastest and safest delivery service.

4、The faster and safest delivery service.

5、The high purity products.

6、We have a sufficient supply of stock.

7、A variety of payments, such as L/C, TT, , MoneyGram or other payments.

Company Information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details:

Metronidazole Basic information

The nitro imidazoles antibiotics Chemical property Application Methods of production

Product Name:	Metronidazole
Synonyms:	1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-Hydroxyethyl-2-methyl-5-nitroimidazole;2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethanol
CAS:	443-48-1
MF:	C6H9N3O3
MW:	171.15
EINECS:	207-136-1
Product Categories:	Active Pharmaceutical Ingredients;API's;Peptide Synthesis/Antibiotics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;FLAGYL;antibiotic
Mol File:	443-48-1.mol

Metronidazole Chemical Properties

mp	159-161 °C(lit.)
storage temp.	2-8°C
solubility	acetic acid: 0.1 M, clear, faintly yellow
form	crystalline
Water Solubility	<0.1 g/100 mL at 20 ºC
Merck	6157
Stability:	Stable. Incompatible with strong oxidizing agents.
NIST Chemistry Reference	Metronidazole(443-48-1)
EPA Substance Registry System	1H-Imidazole-1-ethanol, 2-methyl-5-nitro-(443-48-1)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	40-46-45-39/23/24/25-23/24/25-11
Safety Statements	36/37-45-53-16-7
WGK Germany	3
RTECS	NI5600000
F	8
HS Code	29332990
Hazardous Substances Data	443-48-1(Hazardous Substances Data)

Metronidazole Usage And Synthesis

The nitro imidazoles antibiotics	Metronidazole is a kind of nitroimidazole antibiotics, also called flagyl, has killing effect on anaerobic microorganisms. When it restored in the body, its metabolites also have anti anaerobic bacteria, inhibiting the synthesis of bacterial deoxyribonucleic acid, thus interfering with bacterial growth, reproduction, and ultimately death of bacteria. And general anti anaerobic bacteria including: bacteroides fragilis, fusiform bacilli (it become well-known due to cell shape with sharp spindle shaped ends), tetanus, peptococcus, peptostreptococcus, giardia bacteria. At first, it was used in treatment of vaginal trichomoniasis, clinical effect is very significant. Later it was found that metronidazole can also kill anaerobic bacteria causing oral infection. In 1978, it was determined its anti anaerobic infection effects of drugs by the World Health Organization, widely used in the prevention and treatment of oral anaerobic bacteria infection in hospital. This products are also often used in the prevention and treatment for anaerobic bacteria causing respiratory tract, digestive tract, abdominal cavity and pelvic infection, skin and soft tissue and bone and joint infection, heart meningitis, septicemia and cerebral treatment. Metronidazole has significant effect on amoebiasis in vivo tissue and the intestines, also is the first choice drug for the treatment of toxoplasmosis in the human body, the mechanism is through inhibition of redox reaction of amoebae, rupturing protozoal nitrogen chain and functioned. In vitro test showed that, drug concentration is 1 ~ 2mg / L, soluble Entamoeba histolytica can change their shapes in 6 to 20 hours, and completely killed in 24 hours. The concentration is 0.2mg/L, can kill Entamoeba histolytica in 72 hours. It has been widely used in treatment of intestinal and extraintestinal amebiasis (such as amoebic liver abscess, pleural o Miba disease, etc.). Due to the interaction of nitroimidazole antibiotics, alcohol, nicotine, etc. and interference of ethanol oxidation process, can cause disulfiram reaction, resulting in rapid heart rate, decreasing blood pressure and other symptoms, so patients should be to avoid contact with alcoholic drink, smoke less, so as to avoid the occurrence of adverse drug reactions during treatment. The above information is edited by the Chemicalbook Hanya.
Chemical property	White or milky white crystalline powder. Melting point is 158-160. Soluble in hot water, slightly soluble in ethanol, slightly soluble in water or chloroform, slightly soluble in ether. Bitter and slightly salty.
Application	1.In 1959, the goods were used for the treatment of vaginal trichomoniasis. Since 1970, it has used for the intestine, extraintestinal amebiasis, and it has high efficacy, low toxicity, wide application. it has mutagenic and teratogenic effects on experimental animals. 2.It has strong antibacterial effect on most anaerobic bacteria. 3.It is used for the treatment of amebiasis, trichomoniasis and anaerobic bacteria infection.
Methods of production	It is synthetized by 2-methyl-5-nitro imidazole (see 25010) and ethylene oxide addition. 2-methyl-5-nitro imidazole dissolved in formic acid and at 30-40℃ successive adding epoxy ethane, and sulfuric acid in the middle of adding feeding. and reaction for 1 h, after that. Decompression to recycle formic acid, water solution is cooled to 10 ℃, filter. The filtrate with sodium hydroxide solution to adjust pH = 10. Set aside to cool, filtering, washing to nearly alterations into neutral, recrystallization in water. Activated carbon decolorization to get metronidazole.
Chemical Properties	white to slightly yellow crystalline powder
Usage	Used as an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen.
General Description	White to pale-yellow crystalline powder with a slight odor. Bitter and saline taste. pH (saturated aqueous solution) about 6.5.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	Metronidazole darkens on exposure to light. Metronidazole is incompatible with strong oxidizing agents. .
Fire Hazard	Flash point data for Metronidazole are not available; however, Metronidazole is probably combustible.

Metronidazole Preparation Products And Raw materials

Raw materials

Glyoxal-->Acetaldehyde-->BENZANILIDE-->2-Methylimidazole-->2-Methyl-5-nitroimidazole

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