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Methyl acetoacetate cas no 105-45-3 cas no 105-45-3 3-OXBUTANOIC ACID METHYL ESTER
Methyl acetoacetate Chemical Properties |
mp | -28 °C |
bp | 169-170 °C70 mm Hg(lit.) |
density | 1.077 |
refractive index |
n |
Fp | 158 °F |
storage temp. | 2-8°C |
solubility | 460 g/L (20°C) |
Water Solubility | 460 g/L (20 ºC) |
Merck | 14,6009 |
BRN | 506727 |
CAS DataBase Reference | 105-45-3(CAS DataBase Reference) |
NIST Chemistry Reference | Butanoic acid, 3-oxo-, methyl ester(105-45-3) |
EPA Substance Registry System | Butanoic acid, 3-oxo-, methyl ester(105-45-3) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36 |
Safety Statements | 26 |
WGK Germany | 1 |
RTECS | AK5775000 |
HS Code | 29183000 |
Hazardous Substances Data | 105-45-3(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
MAA | English |
SigmaAldrich | English |
ACROS | English |
ALFA | English |
Methyl acetoacetate Usage And Synthesis |
Chemical Properties | Colorless, clear liquid |
Usage | Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives. |
Usage | 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones. |
General Description | A clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air. |
Air & Water Reactions | Very slightly soluble in water. |
Reactivity Profile | Methyl acetoacetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides |
Health Hazard | May be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation. |
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