Liranaftate

Product information

Liranaftate Basic information

The third generation of dithiocarbamate antifungal Toxicity Synthesis method Liranaftate cream Application

Product Name:	Liranaftate
Synonyms:	carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(5,6,7,8-tetrahydro-2-na;phthalenyl)ester;LIRANAFATE;LIRANAFTATE;M-732;(6-METHOXY-2-PYRIDINYL)-METHYLCARBAMOTHIOIC ACID O-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL) ESTER;PIRITETRATE;ZEFNART
CAS:	88678-31-3
MF:	C18H20N2O2S
MW:	328.43
EINECS:
Product Categories:	All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Liranaftate;API
Mol File:	88678-31-3.mol

Liranaftate Chemical Properties

mp	98.5-99.5°C
storage temp.	-20°C Freezer

Safety Information

MSDS Information

 

Liranaftate Usage And Synthesis

The third generation of dithiocarbamate antifungal	Liranaftate is a new king of third-generation dithiocarbamate antifungals , it is a new kind of the third category of chemicals,it belongs to squalene cyclooxygenase inhibitors, by inhibiting the fungal cell membrane squalene epoxidation reaction , it hinders the synthesis of ergosterol which is a constituent of cell membranes ,it plays the role of anti-fungal,its anti-fungal activity is 8 times of tolnaftate, and its dermatophytes effect is better than clotrimazole. It has a strong anti-fungal effect on skin filamentous fungi (Trichophyton,Microsporon, Epidermophyton) , it also shows antifungal activity on other filamentous fungi, dark fungi, dimorphic fungi.It is useful in the treatment of tinea capitis, ringworm, athlete's foot, tinea pedis, onychomycosis, tinea, jock itch, tinea versicolor and vulvovaginal candidiasis.
Toxicity	Reproductive toxicity: in general reproductive toxicity tests, subcutaneous administration to SD rats , the largest non-toxic dose for the parent is 20mg / kg, the largest non-toxic dose for the reproductive process and their pups is 100mg / kg. Genetic Toxicity: Liranaftate mutagenicity tests are negative. In toxicity tests during teratogenic sensitively period , subcutaneous administration ,the largest non-toxic dose of maternal is 300mg / kg, the largest non-toxic dose to fetal rats is100mg / kg. In perinatal toxicity tests, administer subcutaneously, the largest non-toxic dose for the mother and newborn pups is 30mg / kg. The above information is edited by the chemicalbook of Tian Ye.
Synthesis method	5,6,7,8-tetrahydro-2-naphthol reacts with thiophosgene to give the thio-5,6,7,8-tetrahydro-2-naphthyl chloroformate ester and 2-methoxy-6- methylamine pyridine, then react in isopropanol · water at room temperature for 2 hours to obtain liranaftate ,the overall yield is 70%.
Liranaftate cream	Liranaftate cream is a relatively safe topical antifungal formulation . In mutagenicity studies we found that no matter in chromosome aberration tests, or in the bone marrow micronucleus tests, Liranaftate cream has no effect on inducing cell chromosome aberrations , and it has no effect on bone marrow cell proliferation. It is used for the treatment of ringworm, athlete's foot, ringworm, jock itch, tinea versicolor and vulvovaginal candidiasis. Domestic manufacturers include: Chen Xin Shandong Lukang Pharmaceutical Co., Ltd. (Country medicine accurate words H20052287), Beijing Sihuan Pharmaceutical Technology Co., Ltd. Beijing Shengde Lai Bao Pharmaceutical Co., Ltd., Jiangsu zhongdan Pharmaceutical Co., Ltd.( Country medicine accurate words H20052733 ),Henan Tian Fang Pharmaceutical Co., Ltd. (Country medicine accurate words H20052552), and Nanjing Shenghe Pharmaceutical Co., Ltd. (Country medicine accurate words H20052554), Shideda Pharmaceutical (Beijing) Co., Ltd. (Country medicine accurate words H20052742), Kunshan Reddy pharmaceutical Co., Ltd. (Country medicine accurate words H20052345), Hugang Xinya pharmaceutical (Yangzhou) Co., Ltd. (Country medicine accurate words H20070143), Shandong Weigao pharmaceutical Co., Ltd. (Country medicine accurate words H20070073), Yangtze River pharmaceutical Group Co., Ltd. ( Country medicine accurate words H20080036), Heyuante Fukang pharmaceutical Co., Ltd. (Country medicine accurate words H20080162), Shandong Liangfu pharmaceutical Co., Ltd. (Country medicine accurate words H20080187)
Application	Broad-spectrum antifungal
Chemical Properties	White Crystalline Solid
Usage	A squalene epoxidase inhibitor. Used as an antifungal

Company information

 Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

  Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.

    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.

    We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

    We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.