Diacerein

Diacerein
Diacerein
Diacerein

Diacerein

Min.Order / FOB Price:Get Latest Price

100 Gram

Negotiable

  • Min.Order :100 Gram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

4,5-diacetylrhein HIGH purity by own lab 13739-02-1 DIACEREIN

Quick Details

  • Appearance:Yellow Crystalline Solid
  • Application: 13739-02-1 A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic
  • PackAge:1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25kg,50kg or as customers request
  • ProductionCapacity:100|Kilogram|Month
  • Storage:2-8, cold storage, to avoid light storage.
  • Transportation:BY SEA /BY AIR /BY COURIER

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  • Exhibition in shanghai

 

 

 

 

 

 

 

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Diacerein Basic information
Immunosuppressive drugs Application
Product Name: Diacerein
Synonyms: 1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE;DIACEREIN;DIACERHEIN;DIACETYL RHEIN;1,8-diacetoxyanthraquinone-3-carboxylicacid;4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci;4,5-diacetylrhein;9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid
CAS: 13739-02-1
MF: C19H12O8
MW: 368.29
EINECS: 237-310-2
Product Categories: Miscellaneous Biochemicals;Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 13739-02-1.mol
Diacerein Structure
 
Diacerein Chemical Properties
mp  217-2180C
storage temp.  Refrigerator
CAS DataBase Reference 13739-02-1(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  CB8781000
MSDS Information
Provider Language
1,8-Diacetoxy-3-carboxyanthraquinone English
SigmaAldrich English
 
Diacerein Usage And Synthesis
Immunosuppressive drugs Diacerein is a novel interleukin (IL) -1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect. 
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform. 
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg / L, AUC is 21.3 mg • h / L, T1 / 2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.
Application It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance. 
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis. 
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.
Chemical Properties Yellow Crystalline Solid
Usage A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic
Usage antiinflammatory
Usage A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.
Usage Treatment of Osteoarthritis (Prevent cartilage destruction)

 

 

 

 

 

 

 

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