Acetylsalicylic acid

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

O-ACETYLSALICYLIC ACID O-ACETOXYBENZOIC ACID ACETICYL

Quick Details

Appearance:White Solid
Application:50-78-2
PackAge:As required
ProductionCapacity:100-200|Kilogram|Month
Storage:Store at RT.
Transportation:By air/sea/express

Superiority:

About Certificate

1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)

About Service

1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container

About Company

HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.

We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details:

Product Name:	Acetylsalicylic acid
Synonyms:	O-ACETYLSALICYLIC ACID;O-ACETOXYBENZOIC ACID;ACETICYL;ACETOXYBENZOIC ACID;ACETYLSALICYLIC ACID;ACETYSALICYLIC ACID;ACETYLSALICYLIC ACID IMPURITY D;ALKENYL SUCCINIC ANHYDRIDES
CAS:	50-78-2
MF:	C9H8O4
MW:	180.16
EINECS:	200-064-1
Product Categories:	Pharmaceutical;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Anti-Allergic Agents, Antibiotic;Isotope;LOPROX
Mol File:	50-78-2.mol

Acetylsalicylic acid Chemical Properties

mp	134-136 °C(lit.)
density	1.35
Fp	250 °C
storage temp.	Store at RT.
solubility	H₂O: 10 mg/mL at 37 °C
form	crystalline
color	white
Water Solubility	3.3 g/L (20 ºC)
Merck	14,851
BRN	779271
Stability:	Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc.
CAS DataBase Reference	50-78-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 2-(acetyloxy)-(50-78-2)
EPA Substance Registry System	Benzoic acid, 2-(acetyloxy)-(50-78-2)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36/37/39
RIDADR	UN 1851
WGK Germany	1
RTECS	VO0700000
PackingGroup	III
Hazardous Substances Data	50-78-2(Hazardous Substances Data)

MSDS Information

Provider	Language
Acetylsalicylic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

Acetylsalicylic acid Usage And Synthesis

What’s acetylsalicylic acid	Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhydride. It is a white crystalline powder, odorless, stable in dry air. It will be slowly hydrolyzed to be salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction. Slightly soluble in water, soluble in ethanol, ethyl ether, chloroform, sodium hydroxide solution and sodium carbonate solution. Acetylsalicylic acid has antipyretic analgesic, anti-inflammatory and anti-rheumatism effect, that’s why it is often used for fever, headache, muscle pain, neuralgia, rheumatic fever, acute rheumatic arthritis, gout, etc.; also it has antiplatelet aggregation effect, and can be used for prevention of arterial thrombosis, atherosclerosis, transient cerebral ischemia and myocardial infarction; in addition, acetylsalicylic acid also can be used in the treatment of biliary tract roundworm disease and athlete's foot. 【Pharmacological actions】Acetylsalicylic acid is one of the traditional antipyretic analgesics, as well as the role of platelet aggregation. Acetylsalicylic acid in the body has the characteristics of the antithrombotic, can reduce the formation of obstructive blood clots in surrounding arteries, and inhibit release of platelet response and endogenous ADP, 5 - HT, etc., therefore to inhibit second phase other than the first phase of platelet aggregation. The mechanism of action of acetylsalicylic acid is to make platelets cyclooxygenase acetylation, thus inhibiting the formation of ring peroxide, and TXA2 formation is also reduced as well. At the mean time make the platelet membrane protein acetylation, and inhibit platelet membrane enzyme, which helps to inhibit platelet function. As the cyclooxygenase is inhibited, it impacts blood vessel wall synthesized to be PGI2, the platelet TXA2 synthetic enzymes also to be inhibited; so it would impact formation of both TXA2 and PGI2 when it is large doses. Suitable for ischemic heart disease, after percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, prevent transient ischemic stroke, myocardial infarction and reduce the incidence of arrhythmia. The above information is edited by the Chemicalbook He Liao Pu.
Chemical property	This product is a white crystalline, with melting point 138 ~ 140 ℃, insoluble in water, soluble in alcohol, ether, etc.
Applications	1.Acetylsalicylic acid is the raw material for rodenticide intermediates 4-hydroxycoumarin. 2.Used to make outdoor structural members and equipment parts exposed in highlights, such as the automobile body, agricultural machinery parts, meters and electric lamps, road marking, etc. 3.It is the earliest applied, the most popular and the most common antipyretic analgesics anti-rheumatism medicine, has aspects of pharmacological effects as antipyretic-analgesic and anti-inflammatory, anti-platelet aggregation and works quickly and effectively. Overdosage can be easily diagnosed and treated, with rare allergic reactions. Often used to cold fever, headache, neuralgia, joint ache, muscle pain, rheumatic fever, acute wet sex arthritis, rheumatoid arthritis and toothache, etc. Listed in National Essential Medicine List. Acetylsalicylic acid also works as an intermediate of other medicines.
Production method	Acetylation of salicylic acid: add acetic anhydride (feeding ratio is 0.7889 times of the total salicylic acid) in reaction vessel, and then add two thirds of salicylic acid, stir it and temperature rises. React 40-60min in 81-82℃. Cool it to 81-82 ℃ and keep the temperature for 2h. When free salicylic acid is qualified, cool it to 13 ℃, precipitation crystallization, rejection filter, dry it in 65-70℃ air flow, then we get acetylsalicylic acid.
Category	Toxic substance
Toxicity grading	High toxic
Acute toxicity	Oral-rat LD50: 200 mg/kg; Oral-mice LD50: 250 mg/kg
Flammable hazardous characteristics	Flammable in fire; irritant gas would be decomposed out when heated.
Handling and storage characteristics	Warehouse needs to be ventiIative and dry with low temperature; separate it from oxidant and food additives.
Fire extinguishing agent	Water fog, foam, carbon dioxide, sandy soil.
Occupational standard	TWA 5 mg/m3
Chemical Properties	White Solid
Usage	antifungal
Usage	Axepim Cephalosporin antibiotic
Usage	Analgesic; antipyretic; anti-inflammatory; antithrombotic
General Description	Odorless white crystals or crystalline powder with a slightly bitter taste.
Air & Water Reactions	Slowly hydrolyzes in moist air. Has been involved in dust cloud explosions. Water insoluble. Solution in water is acid to methyl red indicator.
Reactivity Profile	The active ingredient in common aspirin. Incompatible with oxidizers and strong acids. Also incompatible with strong bases. May react with water or nucleophiles (e.g. amines and hydroxy groups). May also react with acetanilide, amidopyrine, phenazone, hexamine, iron salts, phenobarbitone sodium, quinine salts, potassium and sodium iodides, alkali hydroxides, carbonates, stearates and paracetanol.
Fire Hazard	Acetylsalicylic acid is combustible.

Acetylsalicylic acid Preparation Products And Raw materials

Raw materials	Salicylic acid
Preparation Products	Warfarin-->3-CARBETHOXY-4-HYDROXYCOUMARIN-->O-ACETYLSALICYLOYL CHLORIDE-->BENORILATE

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Acetylsalicylic acid