4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide 6-(5-carboxy-3-methyl-2-pentenyl)-7-hydroxy-5-methoxy-4-methyl-phthalid lilly-68618
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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Product Name: | Mycophenolic acid |
Synonyms: | 4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide;6-(5-carboxy-3-methyl-2-pentenyl)-7-hydroxy-5-methoxy-4-methyl-phthalid;lilly-68618;melbex;micofenolicoacido;nsc-129185;(4E)-6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID;6-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-PHTHALANYL)-4-METHYL-4-HEXANOIC ACID |
CAS: | 24280-93-1 |
MF: | C17H20O6 |
MW: | 320.34 |
EINECS: | 246-119-3 |
Product Categories: | Active Pharmaceutical Ingredients;Aromatics Compounds;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Related Substance;Isotopically Labeled Pharmaceutical Reference Standard;antibiotic |
Mol File: | 24280-93-1.mol |
Mycophenolic acid Chemical Properties |
mp | 141°C |
storage temp. | 2-8°C |
solubility | methanol: 50 mg/mL, clear, colorless to faintly yellow |
form | powder |
Merck | 13,6352 |
CAS DataBase Reference | 24280-93-1(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xn,N,T,F |
Risk Statements | 22-61-40-68-50/53-48/25-52/53-36-20/21/22-11 |
Safety Statements | 53-45-36/37-61-22-26-16 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | MP8050000 |
F | 10 |
HazardClass | 6.1(b) |
PackingGroup | III |
MSDS Information |
Provider | Language |
---|---|
Mycophenolic acid | English |
SigmaAldrich | English |
Mycophenolic acid Usage And Synthesis |
Chemical Properties | White to Off-White Powder |
Usage | An antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides. |
Usage | immune suppressant, antineoplastic, antiviral |
Usage | antineoplastic, progestin |
Usage | Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation showed mycophenolic acid to display broad antitumour, antiviral, antifungal and antiprotozoan activities. Its potent immunosuppressant activity led to its commercial development to prevent kidney transplant rejection. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes. |
Usage | Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation showed mycophenolic acid to display broad antitumor, antiviral, antifungal and antiprotozoan activities. Its potent immunosuppressant activity led to its commercial development to prevent kidney transplant rejection. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes. |
Biological Activity | Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo . Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation. |
Mycophenolic acid Preparation Products And Raw materials |
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