3'-AZIDO-3'-DEOXYTHYMIDINE 1-(4-azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1h-pyrimidine-2,4-dione 1-((2R,4S,5S)-4-AZIDO-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-METHYL-1H-PYRIMIDINE-2,4-DIONE
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Zidovudine Basic information |
Product Name: | Zidovudine |
Synonyms: | 3'-AZIDO-3'-DEOXYTHYMIDINE;1-(4-azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1h-pyrimidine-2,4-dione;1-((2R,4S,5S)-4-AZIDO-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-5-METHYL-1H-PYRIMIDINE-2,4-DIONE;AZT;AZIDOTHYMIDINE;ZIDOVUDINE;3’-azido-3’-deoxy-thymidin;bwa509u |
CAS: | 30516-87-1 |
MF: | C10H13N5O5 |
MW: | 283.24 |
EINECS: | |
Product Categories: | Amino Acids;Miscellaneous Natural Products;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;API's;Antiviral;HIV/AIDS/Related Products;API;VIOCIN |
Mol File: | 30516-87-1.mol |
Zidovudine Chemical Properties |
mp | 113-115 °C(lit.) |
refractive index | 47 ° (C=1, H2O) |
storage temp. | −20°C |
solubility | H2O: 50 mg/mL |
Water Solubility | 1-5 g/100 mL at 17 ºC |
Merck | 10123 |
CAS DataBase Reference | 30516-87-1(CAS DataBase Reference) |
EPA Substance Registry System | Thymidine, 3'-azido-3'-deoxy- (30516-87-1) |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 40-36/37/38-20/21/22 |
Safety Statements | 36/37/39-45-36-26 |
WGK Germany | 3 |
RTECS | XP2072000 |
F | 10 |
Hazard Note | Harmful |
Hazardous Substances Data | 30516-87-1(Hazardous Substances Data) |
Zidovudine Usage And Synthesis |
Chemical Properties | Off White Crystalline Powder |
Usage | A potent and selective inhibitor of HIV-1 replication |
Usage | antibacterial |
General Description | Slightly off-white odorless powdery solid. |
Air & Water Reactions | Dust may form an explosive mixture in air. Water soluble. Hydrolysis occurs in strongly basic solutions . |
Reactivity Profile | Zidovudine is a azido compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. |
Fire Hazard | Flash point data for Zidovudine are not available; however, Zidovudine is probably combustible. |
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