1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone,4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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Product Name: | Haloperidol |
Synonyms: | 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine;1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-;1-butanone,4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl);4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanon;4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone;4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4’-fluoro-butyrophenon;4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4’-fluorobutyrophenone;4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone |
CAS: | 52-86-8 |
MF: | C21H23ClFNO2 |
MW: | 375.86 |
EINECS: | 200-155-6 |
Product Categories: | Organics;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Dopamine receptor;Dopamine;API;HALDOL |
Mol File: | 52-86-8.mol |
Haloperidol Chemical Properties |
mp | 152 °C |
storage temp. | Store at RT |
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL |
form | powder |
color | white |
Merck | 4598 |
CAS DataBase Reference | 52-86-8(CAS DataBase Reference) |
NIST Chemistry Reference | Haloperidol(52-86-8) |
EPA Substance Registry System | 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- (52-86-8) |
Safety Information |
Hazard Codes | T,F |
Risk Statements | 60-61-25-36/37/38-43-39/23/24/25-23/24/25-11 |
Safety Statements | 53-26-36/37/39-45-36/37-16 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | EU1575000 |
HazardClass | 6.1(b) |
PackingGroup | III |
Hazardous Substances Data | 52-86-8(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone | English |
SigmaAldrich | English |
Haloperidol Usage And Synthesis |
Chemical Properties | White Crystalline Powder |
Usage | Antidyskinetic; antipsychotic |
Biological Activity | Dopamine antagonist with selectivity for D 2 -like receptors (K i values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively). Subtype-selective NMDA antagonist. |
Haloperidol Preparation Products And Raw materials |
Raw materials | Thionyl chloride-->gamma-Butyrolactone-->Fluorobenzene-->Butyrophenone |
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