Tirofiban hydrochlo...

Tirofiban hydrochloride monohydrate

Tirofiban hydrochloride monohydrate

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98%
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Tirofiban hydrochloride monohydrate 150915-40-5 manufacturer , better price with good quality

Quick Details

  • Appearance:White Solid
  • Application:Pharmaceuticals
  • PackAge:Depended
  • ProductionCapacity:300|Kilogram|Month
  • Storage:KEEP COLD
  • Transportation:BY SEA OR AIR

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Tirofiban hydrochloride monohydrate Basic information
Tirofiban hydrochloride monohydrate Precautions Application
Product Name: Tirofiban hydrochloride monohydrate
Synonyms: TIROFIBAN, HYDROCHLORIDE HYDRATE;Tirofiban HCl;TirofibanHcl142373-60-2/;N-(Butylsulfonyl)-O-[4-(4-piperidynyl)butyl]-L-tyrosine, Hydrochloride Hydrate;(2S)-2-(Butylsulfonylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propanoic acid hydrochloride hydrate;N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride monohydrate;Tirofiban hydrochloride monohydrate;L-Tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, monohydrochloride, monohydrate
CAS: 150915-40-5
MF: C22H39ClN2O6S
MW: 495.07
EINECS:  
Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cardiovascular APIs
Mol File: 150915-40-5.mol
Tirofiban hydrochloride monohydrate Structure
 
Tirofiban hydrochloride monohydrate Chemical Properties
mp  135-137°C
storage temp.  -20°C Freezer
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37-45
MSDS Information
 
 
Tirofiban hydrochloride monohydrate Usage And Synthesis
Tirofiban hydrochloride monohydrate Tirofiban is an anti-angina drug, it is successfully developed by the United States Merck company , Patent Number is EP 478363, and in 1998 it was sold in the United States, the trade name is Aggrastat,it is clinically used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherosclerotic plaque excision patients with in combination with heparin. 
Drugs currently used in clinical are mainly tirofiban hydrochloride injections under the tradename Xin Weining, it is a reversible non-peptide platelet surface glycoprotein (GP) Ⅱb / Ⅲa receptor antagonist, it can competitively inhibit combination of fibrinogen and platelet (GP) Ⅱb / Ⅲa receptor . Intravenous injection is a dose-dependent inhibition of outside human platelet aggregation, prolonged bleeding time,and thrombosis caused by ADP, collagen, arachidonic acid,thromboxane analog U46619 and thrombin. 
In healthy volunteers ,they are injected in routinely recommended doses, the peak plasma concentration is similar to that of steady-state plasma concentrations during the infusion ,T1 / 2 is 2h. Within 0.01 ~ 25 μg / ml dose range, PPB of this product is 65%, independent of concentration. Free drug accounts for 35% in plasma, Vd is 22 ~ 42 L. In healthy volunteers, CL is 213 ~ 314 ml / min, the renal clearance rate is 39% -69% of plasma clearance. 
[Usage ]
(1) tirofiban hydrochloride monohydrate in combination with heparin is used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherectomy artery surgery patients. 
(2) to give this product 0.4μg / (kg · min) bolus, 300 min, followed by a maintenance dose of 0.1μg / (kg · min). Unstable angina or non-Q-wave myocardial infarction patients need an infusion of 48 ~ 108 h. Row PTCA or atherectomy arterial patients need to continue infusion 12 ~ 24 h after surgery.
The above information is edited by the chemicalbook of Tian Ye.
Precautions 1. Adverse reactions: The most common adverse reactions are fever, or bleeding complications; other visible adverse reactions are nausea, headache, rash or urticaria, systemic reactions visible is reduction in platelet count. 
2. Disable: allergy to the drug, the use of tirofiban in patients with thrombocytopenia occurring, there is active bleeding or bleeding constitution history before 30 days, history of intracranial hemorrhage, nearly a month of stroke or brain hemorrhage stroke, intracranial tumors, aneurysms, arteriovenous malformations, vital organs, surgery or severe trauma requiring surgical treatment, patients with aortic dissection, pericarditis, severe hypertension. 
3. caution: recent (1 year) bleeding in patients, with coagulopathy, platelet disorder, or a history of thrombocytopenia, platelet count less than 150 × 109 / L patients who have a history of cerebrovascular disease (1 year) , with recent subdural extracapsular surgery, nearly a month having a major surgery or a history of severe physical trauma, dissecting aneurysm, hemorrhagic retinal diseases, chronic hemodialysis patients.
Application Acute coronary syndrome (angina pectoris, myocardial infarction, surgery hydrant). 
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb / IIIa inhibitor. It can prevent platelet aggregation and thrombosis.
Chemical Properties White Solid
Usage A specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. An antithrombotic used in the treatment of unstable angina
Usage Tirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina.
 
Tirofiban hydrochloride monohydrate Preparation Products And Raw materials
 

 

Details:

Henan Sunlake Enterprise Corporation is located in Henan Province, the central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . These products have been being well exported to Europe , Southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
    We are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,Which finally makes us being a reliable and professional supplier in international market.
     We welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
 
Our Advantages:
I). We have abundant professional production experience.
II). We have our own chemical factory.
III). Sample is free of charge.
IV). Reasonable Price, Excellent Quality & Attentive Service
V). Prompt reply: we can reply your inquiry and email within 24 hours.
VI). Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.
VII). We have passed the LFGB, SGS, STC, HSL and some other tests.
VIII). We have a unity cooperation team.
 

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