(bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide 1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate 2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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Product Name: | Cyclophosphamide monohydrate |
Synonyms: | (bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide;1-bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridinemonohydrate;2-(bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane2-oxidemonohydr;2-(di(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphacyclohexane-2-oxidemonohydra;2h-1,3,2-oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-,2-oxide,mo;-2monohydrate;cyclicn’,o-propyleneesterofn,n-bis(2-chloroethyl)phosphorodiamidicacidm;endoxanmonohydrate |
CAS: | 6055-19-2 |
MF: | C7H17Cl2N2O3P |
MW: | 279.1 |
EINECS: | 200-015-4 |
Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;CYTOXAN;Anti-cancer&immunity |
Mol File: | 6055-19-2.mol |
Cyclophosphamide monohydrate Chemical Properties |
mp | 49-51 °C(lit.) |
Fp | >230 °F |
storage temp. | 2-8°C |
solubility | H2O: 0.1 g/mL, clear, colorless |
Water Solubility | 40 g/L |
Merck | 14,2747 |
BRN | 8167897 |
CAS DataBase Reference | 6055-19-2(CAS DataBase Reference) |
EPA Substance Registry System | 2H-1,3,2-Oxazaphosphorin- 2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate(6055-19-2) |
Safety Information |
Hazard Codes | T |
Risk Statements | 45-25-61-46-36/37/38-23/24/25 |
Safety Statements | 53-45-37/39-26 |
RIDADR | UN 3464 6.1/PG 3 |
WGK Germany | 3 |
RTECS | RP6157750 |
F | 10 |
HazardClass | 6.1 |
PackingGroup | II |
MSDS Information |
Provider | Language |
---|---|
N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester amide monohydrate | English |
SigmaAldrich | English |
ACROS | English |
ALFA | English |
Cyclophosphamide monohydrate Usage And Synthesis |
Chemical Properties | White to Off-White Solid |
Usage | It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. |
Usage | antineoplastic, alkylating agent |
Usage | alkylating agent in cancer therapy |
General Description | Fine white crystalline powder with a slightly bitter taste. Little or no odor. |
Air & Water Reactions | Water soluble. Sensitive to moisture and light. Aqueous solutions may be kept for a few hours above room temperature, but hydrolysis occurs at temperatures above 86°F. Cyclophosphamide monohydrate undergoes both specific acid and specific base catalysis at extreme pHs. Spontaneous hydrolysis in aqueous solutions. |
Reactivity Profile | Polymerization can occur at temperatures > 120° F. Cyclophosphamide monohydrate reacts with strong oxidizing agents, strong acids and strong bases. Benzyl alcohol increases rate of hydrolysis. |
Fire Hazard | Cyclophosphamide monohydrate is probably combustible. |
Cyclophosphamide monohydrate Preparation Products And Raw materials |
Raw materials | 2,2'-Iminodiethanol |
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