- Min.Order :1 Kilogram
- Purity: 98%
- Payment Terms : L/C,D/A,D/P,T/T,Other
Keywords
side chain for biapenem 153851-71-9 manufacturer , better price with good quality
Quick Details
- Appearance:1KG; 20KG
- Application:Pharmaceuticals
- PackAge:Depended
- ProductionCapacity:300|Kilogram|Month
- Storage:KEEP COLD
- Transportation: BY SEA OR AIR
Superiority:
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Preview |
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| BIAPENEM SIDE CHAIN Basic information |
| Outline Reference quality standards The current status of Chinese imipenem drugs |
| Product Name: | BIAPENEM SIDE CHAIN |
| Synonyms: | 6,7-dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride;6,7-DIHYDRO-6-MERCAPTO-5H-PYRAZOLO(1,2-A) (1,2,4)-TRIAZOLIUM CHLORIDE;5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-IUM, 6,7-DIHYDRO-6-MERCAPTO-, CHLORIDE;Side chain for Biapenem;SIDE CHAIN FOR BIAPENEM 97+%（HPLC）;5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium,6,7-dihydr;6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride (the sidechain of biapenem);BIAPENEM SIDE CHAIN |
| CAS: | 153851-71-9 |
| MF: | C5H8ClN3S |
| MW: | 177.66 |
| EINECS: | |
| Product Categories: | Chemical intermediate for Biapenem;API intermediates;(the sidechain of biapenem);Other Products;Pharmaceutical intermediate |
| Mol File: | 153851-71-9.mol |
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| BIAPENEM SIDE CHAIN Chemical Properties |
| CAS DataBase Reference | 153851-71-9(CAS DataBase Reference) |
| Safety Information |
| BIAPENEM SIDE CHAIN Usage And Synthesis |
| Outline | Side Chain for Biapenem belongs to the raw material of medicine pharmaceutical and can be used for the production of biapenem antibiotic drugs. Biapenem (Biapenem, LJC 10627) is a kind of injection-used carbon penicillin vinyl antibiotics developed by Lederle Japan and American Cyanamid in 1989. Now the phase III clinical study has been completed in Japan and it is now waiting for approval for entering into market. The most notable feature of this product is that it is a kind of 1β- methyl carbapenem with its 2-position S containing a bi-cyclic triazole. Structure-efficacy relationship studies have showed that the presence of the side chain quaternary ammonium cation center is the key to the outer membrane permeability, making it have its inhibitory effect on Pseudomonas aeruginosa and anaerobes being 2-4 times as high as that of imipenem; its inhibitory effect on drug resistant pseudomonas aeruginosa is 4 to 8 times as high as meropenem. It is also more effective in treating Acinetobacter spp, anaerobes than ceftazidime. |
| Reference quality standards |
Items Standards Appearance: white to light yellow crystalline powder Determination of content: 98% Specific rotation: -26.0 ° to -36.0 ° PH: ph value should be 4.5 to 6.0 Single impurity: <1.0% Total amount of impurities: <3.0% Tetrahydrofuran and acetone: THF is less than 0.072%, less than 0.5% acetone Loss on weight upon drying: not more than 1.0% Residue upon ignition: not more than 0.2% Heavy metals: not more than 20ppm |
| The current status of Chinese imipenem drugs |
Imipenem drug is by far the antibiotic with the broadest antibacterial spectrum and strong antibacterial activity and therefore plays an important role of the last-line defense for fighting against severe clinical infection. In recent years, owing to the serious issue of drug-resistant strains, there has been rapid growth of these drugs in the world and domestic usage. The world has listed six varieties including imipenem-cilastatin, panipenem-Betamipron, meropenem, biapenem (Side Chain for Biapenem), ertapenem and doripenem. However, imipenem is clinically used as second-line drugs; moreover, the guideline of government for rational application of antibiotics and its expensive price have also greatly limited the expansion of the usage number of imipenem; all these factors have determined that these drugs is still a kind of “noble” drug varieties with high additional value and small scale in the short term. At 2008, the terminal sales scope of imipenem in China market has reached 18.9 billion (US$ 278 million), accounting for 9% of the global total sales which is around $ 3 billion; the sales amount has reached to about 12.43 million which consumes 5-6 tons/year of raw materials from which domestic raw materials are 1.9 tons (among them, 1.8 tons are meropenem, and imipenem accounts for 0.14 tons), accounting for 36%. In the raw materials export market, at 2008, the exports amount of the three major biapenem products in China- meropenem, imipenem and intermediate 4-AA have their raw material exports amount be 6 tons, 1.3 tons and 40 tons, respectively, which was estimated to account for over 60% of the raw material market demand of drugs with global generic name. Since 2009, the international market demand has continuously grown. The imipenem raw material and the technology cost of the intermediate of China have gradually gained advantage, in particular has meropenem occupying a larger scale in the international market with a certain right of speech in the price. In the full year of 2009, it was expected that the export amount of meropenem and 4-AA will reach 8 tons and 50 tons, respectively with a growth rate being 30%. Imipenem drugs will continue to grow rapidly and smoothly in accordance with their own "rhythm." The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Chemical Properties | 1KG; 20KG |
| BIAPENEM SIDE CHAIN Preparation Products And Raw materials |
Details:
Henan Sunlake Enterprise Corporation is located in Henan Province, the central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . These products have been being well exported to Europe , Southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
We are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,Which finally makes us being a reliable and professional supplier in international market.
We welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
Our Advantages:
I). We have abundant professional production experience.
II). We have our own chemical factory.
III). Sample is free of charge.
IV). Reasonable Price, Excellent Quality & Attentive Service
V). Prompt reply: we can reply your inquiry and email within 24 hours.
VI). Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.
VII). We have passed the LFGB, SGS, STC, HSL and some other tests.
VIII). We have a unity cooperation team.
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