- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
TEMOZOLOMIDE 4-methyl-5-oxo-2 tetrazine-8-carboxamide
Quick Details
- Appearance:Off-White to Light-Pink Crystalline Solid
- Application:85622-93-1
- PackAge:As required
- ProductionCapacity:100-200|Kilogram|Month
- Storage:2-8°C
- Transportation:By air/sea/express
Superiority:
About Certificate
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
About Service
1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container
About Company
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
Details:
| Product Name: | Temozolomide |
| Synonyms: | 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;1-d)(1,2,3,5)tetrazine-8-carboxamide,3,4-dihydro-3-methyl-4-oxo-imidazo(;3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide;3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide;8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3h)-one;ccrg81045;m&b39831 |
| CAS: | 85622-93-1 |
| MF: | C6H6N6O2 |
| MW: | 194.15 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Bases & Related Reagents;Heterocycles;Nucleotides;Displays antitumor activity.;API;TEMODAR;Inhibitors |
| Mol File: | 85622-93-1.mol |
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| Temozolomide Chemical Properties |
| mp | 212°C dec. |
| storage temp. | 2-8°C |
| CAS DataBase Reference | 85622-93-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,Xi |
| Risk Statements | 45-46-60-61-22-36/37/38 |
| Safety Statements | 24/25-45-36/37-26-53-36 |
| RTECS | NJ5927050 |
| Chemical Properties | It is crystallized from dichloromethane, m.p. 212 °C (decomposition). UV maximal absorption wavelength (95% ethanol): 327nm. |
| Application | Antineoplastic agents. Spontaneous and rapid degradation and produce the active metabolite MTIC in vivo, yielding anti-tumor effect. |
| Production methods | Amino-4-carboxamido-imidazole is first subject to nitrite diazotization, and has reaction with methyl isocyanate in dichloromethane for cyclization to obtain ammonium temozolomide. |
| Chemical Properties | Off-White to Light-Pink Crystalline Solid |
| Usage | Imidazotetrazine alkylating agent. An antineoplastic. |
| Usage | inhibits cancer cells similar to paclitaxel effective against paclitaxel-resistant tumours |
| Biological Activity | DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC 50 = 5.0 μ M for cytotoxicity against mouse TLX5 lymphoma cells). |
| Temozolomide Preparation Products And Raw materials |
| Raw materials | METHYLISOCYANATE 1 X 500MG NEAT-->5-Amino-4-imidazolecarboxamide |
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