TRETINOIN VITAMIN A ACID TRANS-RETINOIC ACID ALL-TRANS
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5.Nuclear Magnetic Resonance(NMR)
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Product Name: | Tretinoin |
Synonyms: | TRETINOIN;TRETINOIN VITAMIN A ACID;TRANS-RETINOIC ACID;TRANS VITAMIN A ACID;VITAMIN A ACID;VITAMIN A ACID, ALL-TRANS;RETINOIC ACID;RETINOIC ACID, ALL TRANS |
CAS: | 302-79-4 |
MF: | C20H28O2 |
MW: | 300.44 |
EINECS: | 206-129-0 |
Product Categories: | PHARMACEUTICALS;Active Pharmaceutical Ingredients;APIs;Biochemistry;Terpenes;Terpenes (Others);Vitamins;Intermediates & Fine Chemicals;Retinoids;Intracellular receptor;API;intermediates;Inhibitors |
Mol File: | 302-79-4.mol |
Tretinoin Chemical Properties |
mp | 180-181 °C(lit.) |
storage temp. | 2-8°C |
form | powder |
color | yellow |
Water Solubility | insoluble |
Merck | 14,8165 |
BRN | 2057223 |
Stability: | Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months. |
CAS DataBase Reference | 302-79-4(CAS DataBase Reference) |
EPA Substance Registry System | Retinoic acid(302-79-4) |
Safety Information |
Hazard Codes | T,Xn,N |
Risk Statements | 22-63-38-20/21/22-51/53 |
Safety Statements | 53-26-36/37/39-45-36/37-61 |
RIDADR | 3249 |
WGK Germany | 3 |
RTECS | VH6475000 |
F | 7-8-16-23 |
HazardClass | 6.1(b) |
PackingGroup | III |
Hazardous Substances Data | 302-79-4(Hazardous Substances Data) |
Chemical Properties | Yellow-Orange Powder |
Usage | keratolytic, antiacne, antineoplastic |
Usage | antipruritic |
Usage | Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation |
General Description | Yellow to light-orange crystalline powder. |
Air & Water Reactions | Tretinoin may be sensitive to prolonged exposure to air. Insoluble in water. |
Reactivity Profile | Tretinoin may discolor on exposure to light. Tretinoin is extremely sensitive to exposure to light and, therefore, Tretinoin should be fully protected from light during all handling. Solutions are unstable in the presence of strong oxidizers. Tretinoin is incompatible with strong oxidizing agents. . |
Fire Hazard | Flash point data for Tretinoin are not available; however, Tretinoin is probably combustible. |
Biological Activity | Endogenous agonist for retinoic acid receptors. Also positively modulates PPAR δ receptors (K d = 17 nM). Promotes differentiation of embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro . |
Tretinoin Preparation Products And Raw materials |
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