Fosinopril sodium

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

MONOPRIL TENSOZIDE;(4S)-4-CYCLOHEXYL-1-[[(R)-[(1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY](4-PHENYLBUTYL)PHOSPHINYL]ACETYL]-L-PROLINE FOSINOPRIL-D5 SODIUM SALT

Quick Details

Appearance:White to Off-White Crystalline Solid
Application:88889-14-9
PackAge:As required
ProductionCapacity:100-200|Kilogram|Month
Storage:-20°C Freezer
Transportation:By air/sea/express

Superiority:

About Certificate

1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)

About Service

1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container

About Company

HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.

We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details:

Product Name:	Fosinopril sodium
Synonyms:	MONOPRIL;TENSOZIDE;(4S)-4-CYCLOHEXYL-1-[[(R)-[(1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY](4-PHENYLBUTYL)PHOSPHINYL]ACETYL]-L-PROLINE;(4s)-4-cyclohexyl-1-{[(rs)-2-methyl-1-(propionyloxy)propoxy]-(4-phenylbutyl)phosphinylacetyl}-l-proline sodium salt;FOSINOPRIL-D5 SODIUM SALT;FOSINOPRIL NA;FOSINOPRIL SODIUM;FOSINOPRIL SODIUM SALT
CAS:	88889-14-9
MF:	C30H46NNaO7P
MW:	586.65
EINECS:
Product Categories:	API;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Chiral Reagents;Phosphorylating and Phosphitylating Agents;Isotope Labelled Compounds;Cardiovascular APIs
Mol File:	88889-14-9.mol

Fosinopril sodium Chemical Properties

mp	196-198°C
storage temp.	-20°C Freezer
CAS DataBase Reference	88889-14-9(CAS DataBase Reference)

Safety Information

MSDS Information

Fosinopril sodium Usage And Synthesis

Hypotensive drug	Fosinopril sodium is a unique novel angiotensin converting enzyme inhibitor containing phosphono,it is a sodium of fosinopril , belonging to lowering blood pressure drugs in the cardiovascular system drugs , it is originally and successfully developed by the US Bristol-Myers Squibb company , the trade name is Monopril, it was first listed in the UK in 1991, followed by a number of countries including the United States and European countries,it is used for the treatment of hypertension ,and for treatment of heart failure in combination with a diuretic. Fosinopril is a prodrug, after oral absorption,it is hydrolyzed in the gastrointestinal tract and liver to become a diacids complex complex, fosinopril sodium which has pharmacological activity and to play its role. It can competitively bind with ACE active ligand zinc ion , blocking angiotensin Ⅰ becoming into angiotensin Ⅱ, so that the blood vessels are dilate, aldosterone secretion is decreased, and blood pressure is decreased. Its ACE inhibition strength is similar to enalapril. Hypertension patients are treated with fosinopril ,the drug plays its role one hour after administration ,after 2 to 6 hours .it is up to maximum antihypertensive effect, it can hold effect for 24 hours, 1 times / day administration. Fosinopril can reduce peripheral vascular resistance, so that systemic vascular resistance is decreased, the cardiovascular output, left ventricular ejection fraction and left ventricular filling increase, thereby cardiac function is improved . The product also allows renal blood flow, glomerular filtration, plasma volume maintained or improved, renal vascular resistance is decreased, it does not affect cerebral blood flow. Oral bioavailability 36%, the concentration of blood Fosinoprilat reaches the peak 3 hours after the administration, t1 / 2 is 11.5 hours, and for hypertension associated with reduced renal function patients, when they take the drug, there is compensatory increase in hepatic metabolism, and when hypertension associated reduced liver function, renal function increases the elimination of the drug, due to the elimination of this compensatory mechanism, fosinopril treatment for high blood pressure,when it comes to that liver and kidney function is reduced, it is generally not necessary to adjust the dosage. First treatment of hypertension with the drug is an oral dose of 10mg / times, 1 time / day, general therapeutic dose range is 20 ~ 40mg / d. It can"in a lasting time and stably decrease blood pressure to protect heart and kidney , the dual elimination of kidney and liver is safer" because fosinopril sodium- does not have free thiol group, clinically, skin rashes and other allergic reactions caused by mercapto are less generated,it is the based medication for hypertension combined crown heart disease and chronic heart failure patients, it is also the preferred treatment of hypertension and diabetes patients , it is suitable for all strong indications of high blood pressure. Especially for the elderly and patients with liver and kidney dysfunction, the use of the product is more safe and convenient. The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties	White to Off-White Crystalline Solid
Usage	A phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
Usage	A labelled phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor.
Usage	Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

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