S-Trityl-L-cysteine

Product information

 

S-Trityl-L-cysteine Basic information

Product Name:	S-Trityl-L-cysteine
Synonyms:	3-(tritylthio)-l-alanin;3-tritylthio-l-alanine;s-(triphenylmethyl)-l-cystein;H-CYS(TRT)-OH;CYSTEINE(TRT)-OH;EG5 INHIBITOR II;NSC 83265;S-(TRIPHENYLMETHYL)-L-CYSTEINE
CAS:	2799-07-7
MF:	C22H21NO2S
MW:	363.47
EINECS:	218-195-8
Product Categories:	Amino Acids Derivatives;Cysteine [Cys, C];Amino Acids and Derivatives;Amino Acids 13C, 2H, 15N;Amino Acid Derivatives;Amino Acids & Derivatives;Aromatics;Chiral Reagents;Enzyme substrates;Cell Cycle Regulation
Mol File:	2799-07-7.mol

S-Trityl-L-cysteine Chemical Properties

mp	182-183 °C (dec.)(lit.)
refractive index	111 ° (C=0.8, 0.04mol Ethanolic HCl)
storage temp.	-20°C
BRN	2339626
CAS DataBase Reference	2799-07-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	22-24/25
WGK Germany	3
RTECS	AY7710000

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

S-Trityl-L-cysteine Usage And Synthesis

Chemical Properties	almost white to light yellow granular powder
Usage	A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.
Biological Activity	Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.

 Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

  Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.

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