Synephrine

Synephrine

Synephrine

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Synephrine 94-07-5 manufacturer , better price with good quality

Quick Details

  • Appearance:white powder
  • Application:Pharmaceuticals
  • PackAge:Depended
  • ProductionCapacity:300|Kilogram|Month
  • Storage:2-8°C
  • Transportation:BY SEA OR AIR

Superiority:


Preview
CBNumber: CB1129621
Chemical Name: Synephrine
Molecular Formula: C9H13NO2
Formula Weight: 167.21
CAS No.: 94-07-5
 
Synephrine Chemical Properties
mp  187 °C (dec.)(lit.)
storage temp.  2-8°C
Merck  9012
CAS DataBase Reference 94-07-5(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DO7350000
MSDS Information
Provider Language
1-(4-Hydroxyphenyl)-2-(methylamino)ethanol English
SigmaAldrich English
 
Synephrine Usage And Synthesis
Plant Extract Synephrine is a kind of biological active substance, mainly extracted from the orange, tangerine peel, green husk and rutaceae plants, is a traditional Chinese medicine and plays an important role of frutus aurantii immaturus effective component, has a strong heart, increase blood volume contraction, blood vessels, high total peripheral vascular resistance and make the left ventricular pressure and the effect of arterial blood pressure, shock resistance, and the effect that reduce weight, but because the Synephrine has the similar structure to that of jute alkali has excited central nervous, the potential side effects of cardiovascular disease, in recent years it is limited to use in the United States, Canada and other countries.
the extract of frutus aurantii immaturus Synephrine
Figure 1 the extract of frutus aurantii immaturus Synephrine
Pharmacological function The pharmacological effects of Synephrine is stimulant, mainly acts on the adrenaline receptor, the heart also have certain excitation; Can shrink blood vessels elevated blood pressure expansion of the trachea and bronchus; Also has a certain of losing weight and the antidepressant effects, mainly used in the treatment of bronchial asthma clinical shock and hypotension collapse and orthostatic hypotension dyspepsia not gastroptosis etc. Synephrine is a kind of pure natural stimulant, without any side effects and positive reactions, and has been widely used in medicine, food and beverage and other industries.
The above information is edited by the Chemicalbook of Duan Yalan.
Separation and extraction methods At present, the extraction and separation method of high purity Synephrine is not mature, and the commonly used method is mainly cationic bunch of ester exchange method and hydrochloric acid percolation method, etc. Market demands for acid-insoluble ash extract hesperidin contain the Synephrine and is huge, so it is necessary to establish a comprehensive process route to utilize the frutus aurantii immaturus, extraction of frutus aurantii immaturus Synephrine and hesperidin.
Content analysis method With the increasing market demand of Synephrine, Synephrine is more valuable. Studies for detection method of the content is unceasingly thorough, the reported methods are (1) reverse high performance liquid chromatography (RP - HPLC), (2) packed column supercritical fluid chromatography (SFC), (3) the HPLC method, (4) thin layer scanning method, (5) combination with high performance liquid chromatography and thin layer chromatography scanning method, etc.
HPLC method for the determination of synephrine content in hovenia dulcis of rutaceae plants [Test Article] rutaceae plant orange Citrus teticulata Blamco and cultivar dry and mature skin, medicinal herbs called "orange" and "wide" tangerine peel, or lime Citrus aurantiwm L and its cultivar immature fruit, dry or sweet orange C.Sinensis Osbeck dry young fruit, medicinal herbs called orange; Orange and its dry cultivated varieties of young fruit or immature fruit peel, medicinal herbs, green husk. 
1. chromatographic
Column chromatographic conditions: Micropak MCH - 5 c18; Mobile phase: 0.02 mol/L phosphoric acid methanol solution and 0.2% sodium dodecyl sulfate; Column temperature: 50 ℃; Flow rate: 1 ml/min: detection wavelength 275 nm.
2. the preparation of the reference substance solution 
Accurate weight synephrine 4 mg, dilute with 10 ml 0.01 mol/L HCL.
3. the preparation of sample solution 
Take 1 g of fine powder sample in 50 ml taper bottle with plug, add 20 ml methanol, ultrasonic oscillation extraction for 15 min, stand for 4 h, filter, take further filtrate 5 ml in 10 ml of centrifugal pipe plug, 90 ℃ insoluble dry, cool, add 0.01 mol/L of hydrochloric acid and chloroform each 2 ml, dense vibration wave, centrifugal, take supernatant on standby.
4. measurement 
Precision learn each 10 ml of the sample solution and reference substance solution, injection, according to chromatographic analysis condition.
5. Analysis results
Different origin Citrus aurantium, bran fried Bitter Orange Synephrine (n = 6,%)
Figure 2 Different origin Citrus aurantium, bran fried Bitter Orange Synephrine (n = 6,%)
Chemical property Ether hydrochloride, colorless crystalline (ethanol), melting point: 166 ℃ - 167 ℃, [α] 27 d - 52. (C = 7.6 mg/ml, anhydrous methanol). In strong acid, strong alkali ion exchange resin chromatography separation easy occurred in despun role. Crystallization and melting point: 184 ℃- 185 ℃; Hydrochloride crystallization, melting point: 151 ℃ - 152 ℃, soluble in water. Heavy tartrate, 188 ℃ - 189 ℃ (partial decomposition), soluble in water, soluble in ether, hardly soluble in chloroform, ether.
Application Vasopressors. Are used in shock, heart failure, treatment of bronchial asthma and bottom blood pressure during surgery and anesthesia, collapse and shock body, a low blood pressure, etc.
Production Method Rutaceae plant lime Citrus aurantium l. results.
Chemical Properties Off-White to Beige Powder
Usage A α-adrenergic receptor agonist, vasoconstrictor.
Usage anti-obesity
Usage A a-adrenergic receptor agonist, vasoconstrictor
 
Synephrine Preparation Products And Raw materials

 

Details:

Henan Sunlake Enterprise Corporation is located in Henan Province, the central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . These products have been being well exported to Europe , Southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
    We are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,Which finally makes us being a reliable and professional supplier in international market.
     We welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
 
Our Advantages:
I). We have abundant professional production experience.
II). We have our own chemical factory.
III). Sample is free of charge.
IV). Reasonable Price, Excellent Quality & Attentive Service
V). Prompt reply: we can reply your inquiry and email within 24 hours.
VI). Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.
VII). We have passed the LFGB, SGS, STC, HSL and some other tests.
VIII). We have a unity cooperation team.
 

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