115007-34-6 C23H31NO7 Mycophenolate mofetil
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| 1 Kilogram |
Negotiable |
- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
AKOS 92025 MMF 4-Hexenoic acid
Quick Details
- Appearance:As detailed
- Application:115007-34-6
- PackAge:As required
- ProductionCapacity:100-200|Kilogram|Month
- Storage:room temperature
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About Certificate
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
Details:
| Product Name: | Mycophenolate mofetil |
| Synonyms: | AKOS 92025;4-HEXENOIC ACID,6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-,2-(4-MORPHOLINYL)ETHYL ESTER;MMF;2-Morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate;Mycophenolate mofetil;Mycophenolate Mofetil（MMF）;Matimaikaofenzhi;4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)- |
| CAS: | 115007-34-6 |
| MF: | C23H31NO7 |
| MW: | 433.49 |
| EINECS: | 12879-494-5 |
| Product Categories: | API;Anti-cancer & immunity |
| Mol File: | 115007-34-6.mol |
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| Mycophenolate mofetil Chemical Properties |
| CAS DataBase Reference | 115007-34-6(CAS DataBase Reference) |
| Pharmacokinetics | MMF is absorbed rapidly after oral administration with the intestinal wall, liver and other tissues being de-esterified and being quickly converted into active role of MPA. The average bioavailability of oral administration is about 94% of that of the intravenous injection (based on area under the curve of MPA). MMF can’t be detected in normal blood cycle after oral administration. Split off from the original drug, MPA formed inactive mycophenolic acid glucuronide by the metabolism of glucuronide transferase enzyme in the liver. The MPA concentration reaches peak 1h after oral administration, and reaches a second peak due to the enterohepatic circulation effect after 6 ~ 12h of medication. It has a biological half-life of 16 ~ 18h; at clinically effective concentration, 97% of MPA bound to plasma proteins. There is a very small amount of MMF (<1%) is excreted from the urine as MPA prototype from the urine with the majority (87%) being in the form of mycophenolic acid glucuronide excreted from urine, 6% being excreted from feces. MMF absorption is closely related to the liver function with smaller absorption with poorer liver function. |
| Adverse reactions | Mainly include hypertension, atrial fibrillation, orthostatic hypotension, tachycardia, thrombosis, vasodilatation, headache, dizziness, insomnia, anxiety, high cholesterol, blood sugar changes, potassium and calcium metabolism disorders, acidosis, increased alkaline phosphatase, increased creatinine, hyperlipidemia, parathyroid dysfunction, nausea, vomiting, indigestion, and liver function abnormalities. Bone marrow suppression is commonly seen. Disable it upon severe neutropenia. The incidences of fungal dermatitis, skin rashes, Amblyopia and cataract are about 3% to 10%. |
| Precautions |
1. Contraindications: People who are allergic to this drug or mycophenolic acid (MPA); pregnant women and lactating women should be disabled. 2. Take with caution: Patients of severe active digestive diseases, bone marrow suppression, being accompanied by hypoxanthine-guanine phosphoribosyltransferase ribose kinase deficiency, severe heart, and liver dysfunction. |
| Mycophenolate mofetil Preparation Products And Raw materials |
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