93957-55-2 C24H25FNNaO4 Fluvastatin sodium salt

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

FLUVASTATIN NA FLUVASTATIN SODIUM SALT monosodiumsalt

Quick Details

Appearance:Yellow Powder
Application:93957-55-2
PackAge:As required
ProductionCapacity:100-200|Kilogram|Month
Storage:Desiccate at -20°C
Transportation:By air/sea/express

Superiority:

About Certificate

1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)

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1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container

About Company

HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.

We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

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Details:

Product Name:	Fluvastatin sodium salt
Synonyms:	(+/-)-(3R',5S',6E)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYLINDOL-2-YL]-3,5-DIHYDROXY-6-HEPTENOATE, SODIUM;FLUVASTATIN NA;FLUVASTATIN SODIUM;FLUVASTATIN SODIUM SALT;sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate;(r,s-(e))-monosodiumsal(+-)-2-yl);3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoicaci;5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-monosodiumsalt,(r,s-(e))-(6-heptenoicaci
CAS:	93957-55-2
MF:	C24H25FNNaO4
MW:	433.45
EINECS:
Product Categories:	Antihyperlipoproteinemic;Intermediates & Fine Chemicals;Pharmaceuticals;HMG-CoA reductase;API;API Reference Standard
Mol File:	93957-55-2.mol

Fluvastatin sodium salt Chemical Properties

mp	194-197°C
storage temp.	Desiccate at -20°C
CAS DataBase Reference	93957-55-2(CAS DataBase Reference)

Safety Information

MSDS Information

Fluvastatin sodium salt Usage And Synthesis

Commonly used cholesterol-lowering drugs	Fluvastatin sodium salt is commonly used as a cholesterol-lowering drug, cholesterol-lowering effect is very good, the trade name of the commercially available products is Lescol,which is produced by Novartis. Fluvastatin sodium salt is a fully synthetic cholesterol-lowering drug, it belongs to methylglutaryl coenzyme A (HMC-CoA) reductase inhibitors, the main function is performed in the liver ,it can transform HMG-CoA into 3-methyl - 3,5-dihydroxy acid, it can inhibit the synthesis of endogenous cholesterol ,and reduce cholesterol content in liver cells, it can stimulate the synthesis of low density lipoprotein (LDL) receptors,and enhance the uptake of LDL particles, reduce the plasma total cholesterol concentration.it can significantly reduce total cholesterol, LDL cholesterol, triglycerides, and increase high-density lipoprotein cholesterol. The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties	Melting point 194 ~ 197 ℃.
Application	HMG-CoA reductase inhibitors.
production method	1. After condensation of (chloroacetyl) fluorobenzeneand N- isopropyl aniline , the compound (I) is obtained. Then in acetonitrile, under the presence of phosphorus oxychloride, react with N, N- dimethylamino acrolein , the compound (Ⅱ) is obtained. Compound (Ⅱ) in the role of a strong base, after condensation with methyl acetoacetate , and then splitting ,the compound (Ⅲ) is produced. At -77 ~ -74 ℃, the compound (Ⅲ) is added dropwise into a mixture of boron sodium borohydride , methanol, tetrahydrofuran and diethyl methoxy ,stir 30min; cyclic boronic ester obtained in ethyl acetate is treated with 30% hydrogen peroxide; then it is hydrolyzed to obtain fluvastatin sodium. 2. the compound (Ⅳ)is obtained by catalytic hydrogenation of Phloroglucinol . React it With tert-butyldiphenylsilyl chloride to produce the compound (V), and then oxidize it to generate (Ⅵ). After oxidation of chloroperbenzoic acid to obtain (Ⅶ), (Ⅷ) is produced through ring-opening . And then it is oxidized to (IX) . (Ⅺ) is obtained through condensation of (Ⅸ) and intermediate x , after deprotection and hydrolysis, obtain fluvastatin sodium. Intermediate (X) can be made through starting from the compound (I), via formylation, reduction, chlorination, and then reacting with triphenylphosphine .
Chemical Properties	Yellow Powder
Usage	A synthetic HMG-CoA reductase inhibitor. Antilipemic
Usage	Anti- hyperlipoproteinemic;'HMG CoA reductase inhibitor
Biological Activity	Orally active, potent and competitive HMG-CoA reductase inhibitor (IC 50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC 50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo .

Fluvastatin sodium salt Preparation Products And Raw materials

Raw materials

Sodium borohydride-->Triphenylphosphine-->3-Chloroperoxybenzoic acid-->Acrolein-->Furan-->Fluorobenzene-->Methyl acetoacetate-->Allylamine-->tert-Butylchlorodiphenylsilane-->Triethylborane-->N-Isopropylaniline

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