- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
GRISEOFULVIN 6-trimethoxy-6’-methylspiro 6-TRIMETHOXY-6'-METHYL
Quick Details
- Appearance:Crystalline Solid
- Application:126-07-8
- PackAge:As required
- ProductionCapacity:100-200|Kilogram|Month
- Storage:?20°C
- Transportation:By air/sea/express
Superiority:
About Certificate
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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About Company
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
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Details:
| Product Name: | (+)-Griseofulvin |
| Synonyms: | (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE;(2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE;7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy;(2s-trans)-xy-6’-methyl |
| CAS: | 126-07-8 |
| MF: | C17H17ClO6 |
| MW: | 352.77 |
| EINECS: | 204-767-4 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal;Aromatics;Chiral Reagents;VERELAN;Inhibitors |
| Mol File: | 126-07-8.mol |
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| (+)-Griseofulvin Chemical Properties |
| mp | 218-220 °C(lit.) |
| alpha | 354 º (c=1, dimethylform) |
| storage temp. | −20°C |
| Water Solubility | practically insoluble |
| Merck | 14,4549 |
| BRN | 95226 |
| CAS DataBase Reference | 126-07-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Griseofulvin(126-07-8) |
| EPA Substance Registry System | Spiro[benzofuran- 2(3H),1'-[2]cyclohexene]- 3,4'-dione, 7-chloro-2',4,6-trimethoxy- 6'-methyl-, (1'S,6'R)-(126-07-8) |
| Safety Information |
| Hazard Codes | T,Xn |
| Risk Statements | 60-61-40-43-45 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | WG9800000 |
| Hazardous Substances Data | 126-07-8(Hazardous Substances Data) |
| Chemical Properties | It is white or white-like powder. Melting point is 218-224 °C. It is highly soluble in tetrachloroethane, soluble in acetone or chloroform, slightly soluble in methanol or ethanol, and very slightly soluble in water. It is odorless or almost odorless with slightly bitter taste. It is stable to heat. |
| Production methods | Griseofulvin is a antibiotic produced from the culture fermentation broth of Penicillium griseofulvum. |
| Chemical Properties | Crystalline Solid |
| Category | Pesticide |
| Usage | adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic |
| Usage | antifungal, inhibits mitosis in metaphase |
| Usage | Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy. |
| Usage | It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum |
| Toxicity grading | Low toxicity |
| Acute toxicity | Oral - rat LD50: 10000 mg / kg; Oral - Mouse LD50: 50000 mg / kg |
| Flammability hazard characteristics | Combustion can produce toxic chloride gas |
| Storage Characteristics | Treasury: ventilation low-temperature an dry; it should be separately stored and transported from raw materials of food. |
| Extinguishing agent | Dry powder, foam, sand |
| General Description | White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | (+)-Griseofulvin is incompatible with strong oxidizing agents. . |
| Fire Hazard | Flash point data for (+)-Griseofulvin are not available. (+)-Griseofulvin is probably combustible. |
| (+)-Griseofulvin Preparation Products And Raw materials |
| Raw materials | Starch-->Oxalic acid |
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