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VINBLASTINE SULFATE SALT incaleukoblastine velban
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
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Product Name: | Vinblastine sulfate |
Synonyms: | 29060le;exal;nsc49842;rozevinsulfate;velban;velbe;vincaleukoblastine,sulfate(1:1)(salt);VINBLASTINE SULFATE SALT |
CAS: | 143-67-9 |
MF: | C46H60N4O13S |
MW: | 909.05 |
EINECS: | 205-606-0 |
Product Categories: | Active Pharmaceutical Ingredients;APIs;VINBLASTINE SULPHATE;Intermediates & Fine Chemicals;Pharmaceuticals;Caspases/Apoptosis;Chiral Reagents;Heterocycles;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;VELBAN;Antineoplastic;Anti-cancer & immunity;Inhibitors |
Mol File: | 143-67-9.mol |
Vinblastine sulfate Chemical Properties |
mp | 267 °C (dec.)(lit.) |
alpha | -21.7 º (c=2, CH3OH 21 ºC) |
storage temp. | 2-8°C |
solubility | H2O: 10 mg/mL |
form | powder |
color | white |
Water Solubility | >=1 g/100 mL at 24.5 ºC |
Merck | 13,10044 |
CAS DataBase Reference | 143-67-9(CAS DataBase Reference) |
EPA Substance Registry System | Vincaleukoblastine, sulfate (1:1) (salt)(143-67-9) |
Safety Information |
Hazard Codes | Xn,T |
Risk Statements | 22-37/38-41-61-36/37/38-63-23/24/25 |
Safety Statements | 26-36/39-53-45-37/39-36/37/39 |
RIDADR | 1544 |
WGK Germany | 3 |
RTECS | YY8400000 |
F | 8-10 |
HazardClass | 6.1(a) |
PackingGroup | II |
MSDS Information |
Provider | Language |
---|---|
Vinblastine sulfate | English |
SigmaAldrich | English |
ACROS | English |
Vinblastine sulfate Usage And Synthesis |
Chemical Properties | Crystalline Solid |
Usage | antineoplastic, spindle poison |
Usage | Labelled Vinblastine (V314000). Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic. |
General Description | An anticancer drug. White to slightly yellow crystalline powder. |
Air & Water Reactions | Water soluble..Rapidly hydrolyzes. |
Reactivity Profile | Vinblastine sulfate is sensitive to light, hydrolysis, oxidation, and heat. Vinblastine sulfate is very hygroscopic. . |
Health Hazard | SYMPTOMS: Symptoms of exposure to Vinblastine sulfate include temporary mental depression, paresthesias, loss of deep-tendon reflexes, headache, convulsions, psychoses; dysfunction of the autonomic nervous system, with marked constipation, paralytic ileus, urinary retention, bilateral pain and tenderness of the parotid glands associated with dryness of the mouth, sinus tachycardia; nausea, vomiting, anorexia, diarrhea; loss of hair, vesicular mucositis of the mouth, and dermatitis. |
Fire Hazard | Flash point data for Vinblastine sulfate are not available; however Vinblastine sulfate is probably combustible. |
Biological Activity | Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. |
Vinblastine sulfate Preparation Products And Raw materials |
Preparation Products | DESACETYLVINBLASTINEAMIDE |
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