- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
15-dihydroxy-9-oxo 5-oxocyclopentaneheptanoicacid 5-OXO-CYCLOPENTANEHEPTANOIC ACID
Quick Details
- Appearance:Crystalline Solid
- Application:745-65-3
- PackAge:As required
- ProductionCapacity:100-200|Kilogram|Month
- Storage:-20°C
- Transportation:By air/sea/express
Superiority:
About Certificate
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
About Service
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2. Prompt shipment with professional documents
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4. Mixed containers with different mixed items in one container
About Company
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
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Details:
| Product Name: | Prostaglandin E1 |
| Synonyms: | (-)-protaglandine1;11,15-dihydroxy-9-oxo-,(11-alpha,13e,15s)-prost-13-en-1-oicaci;l-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoicacid;l-cyclopentaneheptanoicaci;l-pge1;l-protaglandine1;3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOIC ACID;ALPROSTADIL |
| CAS: | 745-65-3 |
| MF: | C20H34O5 |
| MW: | 354.48 |
| EINECS: | 212-017-2 |
| Product Categories: | Miscellaneous Biochemicals;Prostaglandins;Prostaglandin;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Prostanoid receptor and related;Prostaglandin E1, Edex, Muse, Liprostin |
| Mol File: | 745-65-3.mol |
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| Prostaglandin E1 Chemical Properties |
| mp | 115-116 °C |
| alpha | -64 º (c=1.0, C2H5OH) |
| storage temp. | −20°C |
| solubility | ethanol: 1 mg/mL |
| form | powder |
| Water Solubility | insoluble |
| Merck | 13,7968 |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-61 |
| Safety Statements | 36-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GY4569800 |
| F | 8-10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29375000 |
| Chemical Properties | Crystalline Solid |
| Production method |
Sheep seminal vesicles were uesd as raw material for the preparation of PGE crude , with enzyme preparation, incubation, organic solvent extraction, silica gel column separation. The preparation of PGE crude: sheep seminal vesicles [KCl, EDTANa2, PH8] → enzyme suspension [hydroquinone, glutathione] → [arachidonic acid, O2] reaction solution [acetone, ether, methylene chloride] → PGS crude [Separation] → [silica gel] PGE crude Preparation PGE1 finished product: per 1g PGE crude product used 20g silica gel, 10 times the mass of PGE activated silver nitrate silica gel from 200-250 mesh was suspended in expansion agents including: V ethyl acetate : V acetic acid: V petroleum ether: V water = 220: 22.5: 125 : 5 (bp of petroleum ether is 90-120 ℃) , with wet packed column. A small amount of the crude product was dissolved in the same expansion agents, put in the column , eluted. PGE1 and PGE2 were collected . The PGE1 part was put below 35 ℃ to nitrogen concentrating until acetic acid odor was removed, ethyl acetate was added to dissolve, added acid to wash, pH4-5, saline was added to remove silver. The ethyl acetate solution was set in the refrigerator overnight to get finished PGE1 . |
| Usage | A primary Prostaglandin; easily crystallized from purified biological extracts. Vasodilator (peripheral) |
| Usage | Vasodilator;Prostaglandin receptor agonist |
| Biological Activity | Prostaglandin with some selectivity for EP 3 and EP 4 receptors (K i values are 1.1, 2.1, 36, 10 and 33 nM for mouse EP 3 , EP 4 , EP 1 , EP 2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo . |
| Prostaglandin E1 Preparation Products And Raw materials |
| Raw materials | Hydrogen-->Silver nitrate-->2-N-BUTOXYETHYL METHACRYLATE-->Cyclopentene-->Arachidonic acid-->Prostaglandin E2 -->GAMMA-LINOLENIC ACID METHYL ESTER-->Glutathione |
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