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Tenofovir 147127-20-6 C9H14N5O4P
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Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.
Details:
| Tenofovir Basic information |
| Antiviral drugs Pharmacokinetics Indications Preparation Adverse effects |
| Product Name: | Tenofovir |
| Synonyms: | 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;D,L-TENOFOVIR;TENOFOVIR;(R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE;(R)-9-(2-Phosphonomethoxypropyl)Adenine;Tenofovir(ForResearchOnly);(R)-PMPA;[[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid |
| CAS: | 147127-20-6 |
| MF: | C9H14N5O4P |
| MW: | 287.21 |
| EINECS: | |
| Product Categories: | Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Inhibitors |
| Mol File: | 147127-20-6.mol |
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| Tenofovir Chemical Properties |
| mp | 276-280°C |
| storage temp. | Store at -20°C |
| Water Solubility | 13.4 mg/mL (25 ºC) |
| CAS DataBase Reference | 147127-20-6(CAS DataBase Reference) |
| Safety Information |
| Tenofovir Usage And Synthesis |
| Antiviral drugs |
Nucleoside antiviral drugs are synthetic nucleotide analogs, its chemical structure is simple, easy to modified and synthesis. It is the fastest growing antiviral drugs, a new series of high efficiency and low toxicity of nucleoside analogues against viral medicine have been used in HIV infection and HBV infection treatment. In view of structure, nucleoside analogs drug can be divided into purine and pyrimidine categories. According to main effect, nucleoside analogs drug can be divided into Anti-reverse transcriptase (RT) virus drugs, anti-hepatitis virus drugs, anti-herpes virus drugs and other anti-viral drugs and so on. Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA). Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus). The above information is edited by the Chemicalbook YangDongmei. |
| Pharmacokinetics | Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil. Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h. |
| Indications | Tenofovir is indicated for |
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