Probenecid 57-66-9 C13H19NO4S
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Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.
Probenecid Basic information |
Anti-gout drug Indications Adverse reactions Chemical Properties Application Production methods |
Product Name: | Probenecid |
Synonyms: | 4-((dipropylamino)sulfonyl)-benzoicaci;4-(Dipropylsulfamoyl)benzoic acid;4-(dipropylsulfamoyl)benzoicacid;4-[(dipropylamino)sulfonyl]-benzoicaci;Apurina;benacen;Benemid;benemide |
CAS: | 57-66-9 |
MF: | C13H19NO4S |
MW: | 285.36 |
EINECS: | 200-344-3 |
Product Categories: | Miscellaneous;API;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API's;Vanilloid/TRPV channel;chemical additive;pharmaceutical intermediate;PROBENEMID;pharmaceutical chemicals;Pharmaceutical raw materials |
Mol File: | 57-66-9.mol |
Probenecid Chemical Properties |
mp | 194-196°C |
storage temp. | Store at RT |
Water Solubility | <0.1 g/100 mL at 20 ºC |
Merck | 14,7754 |
Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 57-66-9(CAS DataBase Reference) |
NIST Chemistry Reference | P-(dipropylsulfamoyl) benzoic acid(57-66-9) |
EPA Substance Registry System | Benzoic acid, 4-[(dipropylamino)sulfonyl]- (57-66-9) |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 22-40 |
Safety Statements | 36/37 |
RIDADR | 3249 |
WGK Germany | 3 |
RTECS | DG9400000 |
Hazardous Substances Data | 57-66-9(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
4-[(Dipropylamino)sulfonyl]benzoic acid | English |
SigmaAldrich | English |
ALFA | English |
Probenecid Usage And Synthesis |
Anti-gout drug | Probenecid is a chemically synthetic sulfa anti-gout drug, also known as oxybenzone sulfonamides, which has dual role of both promoting the excretion of uric acid excretion and inhibiting the excretion of penicillin. Clinically it is used for treating chronic gout and suppressing excretion of penicillin-type drugs in order to increase their clinical plasma concentration as an adjuvant drug of penicillin therapy. Its mechanism of action is inhibiting the re-absorption of renal tubular on uric acid, thus increasing uric acid excretion and further lowering plasma uric acid concentration for reducing the deposition of urate in tissues and prevent the crystallization of urate. This product can also promote the dissolution of the pre-formed urate, thereby reducing its damage on the joint. In addition, the product can also competitively inhibit the secretion of a weak organic acid (such as penicillin, cephalosporins) in the renal tubules, which can increase blood concentrations of these antibiotics and prolong their duration of action. This product is easy for oral administration |
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