CAS:196597-26-9 C21H26ClN Terbinafine Hydrochloride

CAS:196597-26-9 C21H26ClN Terbinafine Hydrochloride

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500 Gram	Negotiable

500 Gram

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Purity: 99%
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CAS:196597-26-9 C21H26ClN Terbinafine Hydrochloride CAS:196597-26-9 C21H26ClN factory price high purity 99% CAS:196597-26-9 C21H26ClN technical grade or OLED grade

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Appearance:white poweder
Application:CAS:196597-26-9 C21H26ClN technical grade or OLED grade
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ProductionCapacity:1|Metric Ton|Day
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Terbinafine Hydrochloride Basic information

Dermatologist Broad-spectrum Antifungal Drugs Pharmacokinetics Indications Usage and Dosage Chemical Properties Usage

Product Name:	Terbinafine Hydrochloride
Synonyms:	(e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethylaminehydroc;lamosil;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmon;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmonohydrochloride;TERBINAFINE HCL;N-[(2E)-6,6-DIMETHYL-2-HEPTEN-4-YNYL]-N-METHYL-1-NAPHTHALENEMETHANAMINE;TRANS-N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-1-NAPHTHYLMETHYLAMINE HYDROCHLORIDE;(e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamine monohydrochloride
CAS:	78628-80-5
MF:	C21H26ClN
MW:	327.89
EINECS:	245-385-8
Product Categories:	Antifungal;APIs;Acetylenes;Antifungals for Research and Experimental Use;Biochemistry;Functionalized Acetylenes;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Terbinafine;LAMISIL
Mol File:	78628-80-5.mol

Terbinafine Hydrochloride Chemical Properties

mp	204-208°C
storage temp.	-20°C Freezer
Merck	9156
CAS DataBase Reference	78628-80-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,N
Risk Statements	36/37/38-50/53
Safety Statements	26-36/37/39-61-60
RIDADR	UN 3077 9/PG 3
RTECS	QJ8600100

MSDS Information

Terbinafine Hydrochloride Usage And Synthesis

Dermatologist Broad-spectrum Antifungal Drugs	Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It is developed by Swiss Novartis in the 1980 s, and appeared in the market of UK for the first time in 1991. Approved by FDA of the United States for OTC drugs in 1996, and appeared in the market of the United States in the same year. At present, the drug is been sold in more than 90 countries of the word. It can specificity trouble the late biological decomposition of fungus sterol, selectively inhibit the activity of fungal squalene ring oxidase, and inhibit the squalene epoxidation in the formation of ungal cell membrane, thus to kill or inhibit the active of the fungus. Suitable for treatment of candidiasis skin, such as tinea manuum, tinea, tinea, ringworm of the body, tinea versicolor, it is also the best medicine for the treatment of onychomycosis. Terbinafine hydrochloride entered the the first batch of country announced OTC directory in 2000. This product belongs to antifungal drugs. It has strong effect on shallow fungal infection, and can cure most of the fungal skin diseases through external use.
Pharmacokinetics	According to reports in the literatures, after 250 mg of Terbinafine hydrochloride been taken orally, it reaches peak plasma concentration of 0.97 m ug/ml within 2 hours. The absorption half-life is 0.8 hours, spread half-life is 4.6 hours, the degree of biological application is slightly affected by eating, but not used for dose adjustments. The combination rate of drugs and plasma protein is 99%, and can quickly disperse and concentrate in the lipophilic corneous layer through the dermis. Terbinafine hydrochloride can be spread in the skin, therefore, a very high concentration can be reached in the hair follicle, hair and skin layers of fat, and it can enter in the deck in the last few weeks of healing. The metabolites after the bioconversion have no antifungal activity, then discharged through urine. The half-life is 17 hours, no accumulation in the body, and its steady blood drug concentration is not affected by age. But the alleviation rate can reduce for people with liver and kidney disorders, thus triggers blood drug concentration decreasing.
Indications	1.Skin, hair and nail infection caused by Btrichophyta (white hair versicolor bacterium, Trichophyton mentagrophytes, Trichophyton verrucosum, trichophyton tonsurans and Trichophyton violaceum, etc.), microsporum canis, epidermophyton floccosum, ect. 2.Skin yeast infections caused by all kinds of tinea disease (ringworm of the body, tinea, tinea manus and tinea capitis, etc.) and candida (candida albicans, etc.). 3.Onychomycosis (nail fungus infection) caused by molds.
Usage and Dosage	Local external use: apply adequate amount to the affected area and its surrounding, 1-2 times a day. Ringworm of the body, 2-4 weeks, tinea of feet and hands, tinea versicolor, 4 to 6 weeks. Oral: 0.25 grams each time for adult, once per day, period of treatment is as follows: Skin infection treatment: tinea of feet and hands [toe (means) and plantar]: 2 ~ 6 weeks; Ringworm of the body, tinea, 2 ~ 4 weeks. Skin candidiasis: 2 ~ 4 weeks. normal skin appearance and loss of infection can only be visible in a few weeks for curing. Hair and scalp infection treatment: tinea capitis: 4 weeks, tinea capitis most happen in children. Onychomycosis: The most treatment course of patients is 6 weeks to three months. Young patients with normal growth can shorten the treatment course, and less than 3 months of treatment may be enough in addition to the thumb (foot) armour. In other cases, the treatment is usually 3 months. Some patients, especially whose thumb (toe) infected, may take 6 months or longer. The treatment may take more than 3 months if the nail grew slowly in the first week. In healing of mycology and stopping for a few months after treatment, the continuous improvement of nail appearance then completely normal can be seen, this is because that the healthy tissue growth needs time.
Chemical Properties	White crystalline powder. Melting point is 204-208 oC.
Usage	Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It has a significant effect on all kinds of tinea diseases , including fungus, trichophyton, ringworm of the body, tinea, tinea versicolor and onychomycosis caused by dermophyte. It can also be used for bronchial asthma, asthmatic bronchitis and emphysema, etc. This information is edited by ChemicalBook Xiao Nan.
Chemical Properties	Crystalline Powder
Usage	An orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal.

Terbinafine Hydrochloride Preparation Products And Raw materials

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Terbinafine hydrochloride

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