Dimenhydrinate 523-87-5

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : D/A,D/P,T/T

Keywords

Dimenhydrinate 523-87-5 C17H21NO.C7H7ClN4O2

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Appearance:detailed in specifcations
Application:Aripiprazole Intermediate
PackAge:as needed
ProductionCapacity:500|Metric Ton|Month
Storage:Keep in dry and cool condition
Transportation:by air or sea

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Company information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

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Dimenhydrinate Basic information

Anti-motion sickness Traits Effect Medicine interactions Precautions Adverse reactions Application

Product Name:	Dimenhydrinate
Synonyms:	THEOHYDRAMINE;N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMMONIUM 8-CHLORO-THEOPHYLLINATE;DRAMAMINE;DIMENHYDRINATE;2-(benzhydryloxy)-n,n-dimethylethylamine 8-chlorotheophyllinate;8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione compound with 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1);2-(benzhydryloxy)-n,n-dimethylethylaminecompd.with8-chlorotheophylline;2-(diphenylmethoxy)-n,n-dimethylethylamine8-chlorotheophyllinate
CAS:	523-87-5
MF:	C17H21NO.C7H7ClN4O2
MW:	469.97
EINECS:	208-350-8
Product Categories:	Amines;Aromatics;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;DRAMAMINE
Mol File:	523-87-5.mol

Dimenhydrinate Chemical Properties

mp	102-107°C
Water Solubility	Slightly soluble (0.1-1 g/100 mL at 22 ºC)
CAS DataBase Reference	523-87-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-61-36/37/38
Safety Statements	22-26-36/37/39-53
WGK Germany	3
RTECS	XH5082000
Hazardous Substances Data	523-87-5(Hazardous Substances Data)

MSDS Information

Provider	Language
N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate	English
SigmaAldrich	English

Dimenhydrinate Usage And Synthesis

Anti-motion sickness	Dimenhydrinate is a complex salt of diphenhydramine and 8-chloro-theophylline. Antihistamine effect is weaker than diphenhydramine , and its anti-motion sickness and antiemetic effects are stronger. Mainly it is used to prevent and control nausea, vomiting, dizziness and Meniere's syndrome caused by motion sickness, .It is effective to treat a variety of dizziness, vomiting caused by radiation therapy, pregnancy, surgery, inner ear infections, and the use of drugs (such as streptomycin) .
Traits	Dimenhydrinate is transparent white crystalline powder, odorless, slightly soluble in water, soluble in ethanol.
Effect	As a complex salt of diphenhydramine and 8-chloro-theophylline,its role is the same as diphenhydramine hydrochloride, but its anti-histamine effect is weaker than the latter. It can inhibit medulla vomiting chemosensory area and it has a general central pivot inhibition effect and anticholinergic effects, which makes it have sedative and antiemetic effects. It is quickly and completely absorbed after oral administration, it is effective after 15 to 60 minutes , the role is sustainable after 3-6 hours, the elimination phase half-life (t1 / 2β) is 4 ~ 6 hours, plasma protein binding rate is high. Mainly it is metabolized in the liver, it is excreted in urine in the form of metabolites . Patients with hepatic insufficiency using this service,because it can accumulate in the body , the dose should be reduced. The above information is edited by the chemicalbook of Tian Ye.
Medicine interactions	1.It can not be taken with other CNS depressants and it cannot be taken after drinking. 2. It can be used to make ethanol, central nervous system depressants, tricyclic antidepressants more effective. It can momentarily affect barbiturates and sulfacetamide sodium absorption; if it is used with sodium aminosalicylate , plasma concentration of the latter is decreased. 3. Administration with food or milk can reduce the irritation of the stomach of the drug .
Precautions	1. The composition of the production and other ethanolamine allergies, newborns and premature infants are disabled. 2. It pregnant women in early pregnancy within four months use the drug, the incidence of congenital cardiovascular abnormalities and inguinal hernia of the fetus may be increased, the relationship with drug use has not been confirmed. Early pregnancy should not take this product. 3. The anti-emetic effect of the product can adds difficulty in diagnosing appendicitis and drug-induced reactions. 4. Lethargy , inability to concentrate etc.,can occur after treatment, ,patients should not drive cars, boats, etc., and it is not suitable to engage in the highly difficult and dangerous machine operation.
Adverse reactions	Low toxicity, high doses can cause drowsiness, and even cause a rash. Long-term use may cause blood diseases.
Application	It is suitable for motion -sickness, pregnancy, radiation therapy , surgery etc. induced nausea , vomiting and dizziness.
Chemical Properties	White Solid
Usage	Used for treating vertigo, motion sickness, and nausea associated with pregnancy
Usage	An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).
General Description	Crystalline white powder.
Air & Water Reactions	Slightly soluble in water. Slightly acidic.
Health Hazard	SYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.
Fire Hazard	Flash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.

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