COLISTIN 1066-17-7 factory
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COLISTIN Basic information |
Product Name: | COLISTIN |
Synonyms: | COLISTIN;colimycin;colisticina;colomycin;coly-mycin;colymysins;kangdisu;kolimitsin |
CAS: | 1066-17-7 |
MF: | C52H98N16O13 |
MW: | 1155.43 |
EINECS: | 213-907-3 |
Product Categories: | |
Mol File: | 1066-17-7.mol |
COLISTIN Chemical Properties |
Safety Information |
RIDADR | 3249 |
HazardClass | 6.1(b) |
PackingGroup | III |
COLISTIN Usage And Synthesis |
Usage | Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect. |
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