- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
6-methylenandrosta-1 6-METHYLENEANDROSTA AROMASIN
Quick Details
- Appearance:white to light yellow crystal powder
- Application:107868-30-4
- PackAge:As required
- ProductionCapacity:100-200|Kilogram|Month
- Storage:Store at -20°C
- Transportation:By air/sea/express
Superiority:
About Certificate
1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)
About Service
1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container
About Company
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.
We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
Details:
| Product Name: | Exemestane |
| Synonyms: | 6-methylenandrosta-1,4-diene-3,17-dione;6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE;10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-;EXEMESTANE;FCE-24304;AROMASIN;Exemestan;Exemestance |
| CAS: | 107868-30-4 |
| MF: | C20H24O2 |
| MW: | 296.4 |
| EINECS: | |
| Product Categories: | Active Pharmaceutical Ingredients;chiral;Antineoplastic (Hormonal);Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pfizer compounds;Steroid and Hormone;API;Anti-cancer&immunity;Inhibitors |
| Mol File: | 107868-30-4.mol |
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| Exemestane Chemical Properties |
| mp | 155.13°C |
| storage temp. | Store at -20°C |
| CAS DataBase Reference | 107868-30-4(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,N |
| Risk Statements | 60-61-51 |
| Safety Statements | 53-22-36/37-57 |
| Hazardous Substances Data | 107868-30-4(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 10,13-Dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene- | English |
| Chemical properties | White solid, melting point 190 ~ 192℃. |
| Applications |
1.The second generation aromatase inhibitors, used for the treatment of metastatic breast cancer and used as adjuvant therapy for early breast cancer. 2.Pharmaceutical raw materials, is a kind of irreversible steroid body aromatase extinguishing agent, can inhibit the synthesis of estrogen, and reduce circulating estrogen levels, applicable to the progression of disease after treatment with tamoxifen in postmenopausal patients with advanced breast cancer. |
| Producing method | Androst-4-ene-3, 17-dione (2) and triethyl orthoformate dissolved in tetrahydrofuran and anhydrous ethanol, reacting under the presence of p-toluenesulfonic acid, and then add into N-methyl aniline and formaldehyde solution to continue the reaction. The obtained Mannich reaction product dissolved in anhydrous benzoic acid and anhydrous two alkyl, under the action of DDQ, to get exemestane, and the total yield is 45%. |
| Chemical Properties | white to light yellow crystal powder |
| Usage | An antineoplastic (hormonal) |
| Usage | antiinfective |
| Usage | Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry. |
| Exemestane Preparation Products And Raw materials |
| Raw materials | Etanol-->Tetrahydrofuran-->Formaldehyde-->p-Toluenesulfonic acid-->Benzoic acid |
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