3093-35-4 C24H32ClFO5 Halcinonide

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

halciderm HALCINONIDE halcort

Quick Details

Appearance:White or off-white crystalline powder
Application:3093-35-4
PackAge:As required
ProductionCapacity:100-200|Kilogram|Month
Storage:room temperature
Transportation:By air/sea/express

Superiority:

About Certificate

1.Certificate Of Analysis (COA)
2.Material Safety Data Sheet (MSDS)
3.Route of synthesis (ROS)
4.Method of Aanlysis(MOA)
5.Nuclear Magnetic Resonance(NMR)

About Service

1. Quality control, before shipment, free sample for test.
2. Prompt shipment with professional documents
3. Packing as your request, with photo before shipment
4. Mixed containers with different mixed items in one container

About Company

HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.

We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details:

Product Name:	Halcinonide
Synonyms:	20-dione,21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-pregn-4-ene-cyc;halciderm;halcimat;halcort;halog;lic16,17-acetalwithacetone;(11b,16a)-21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione;HALCINONIDE
CAS:	3093-35-4
MF:	C24H32ClFO5
MW:	454.96
EINECS:	221-439-6
Product Categories:	Organics;Cortisone;Hormones;Steroid Hormones;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;API
Mol File:	3093-35-4.mol

Halcinonide Chemical Properties

CAS DataBase Reference

3093-35-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	63
Safety Statements	36
WGK Germany	3
RTECS	TU5010200

MSDS Information

Provider	Language
(11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione	English
SigmaAldrich	English

Halcinonide Usage And Synthesis

Outline	Halcinonide is an efficient synthetic fluorine and chlorine corticosteroid, the effect of it is similar to fludrocortisone . It has strong anti-inflammatory, anti-allergic, anti-itching, inhibiting proliferation of immune effects, topical application can reduce the permeability of the capillary wall and cell membrane,and reduce the inflammatory exudate, and inhibit histamine and other inflammatory mediators formation and release.it is clinically used for subacute or chronic non-infectious skin diseases such as psoriasis, eczema, neurodermatitis, contact dermatitis, seborrheic dermatitis (non-face), atopic dermatitis, flat moss and discoid lupus erythematosus and the like which are hormone therapy ineffective .
Physical and Chemical Properties	White or off-white crystalline powder, odorless. Almost insoluble in water, slightly soluble in ethanol or methanol, soluble in acetone and chloroform. Sealed.
Pharmacological effects	This drug is a potent synthetic glucocorticoid ,its action is similar to fludrocortisone. It has strong anti-inflammatory, anti-allergic, anti-itching, inhibit proliferation of immune and other effects, topical application are unlikely to cause systemic adverse reactions. The drug has the same effect of inhibiting the proliferation of granulation tissue as dexamethasone ,it is stronger than hydrocortisone. The drug is not substantially absorbed in external skin, it has no irritating effect on the body. The extent of absorption of topical application is hugely different among anatomic sites: forearm 1%, 4% of the scalp, forehead, 7%, 36% of the scrotum, the greatest penetration is in the groin, armpits and face. The drug is mainly metabolized in the liver, it is mostly excreted by the kidneys, and less by biliary excretion. The above information is edited by the chemicalbook of Tian Ye.
Indications	The drug is suitable for treatment of contact dermatitis, atopic dermatitis, lichen,the small size of psoriasis, lichen, heat rash, genital atrophic lichen sclerosus, non-parasitic prurigo, ring granuloma, discoid lupus erythematosus, non-facial seborrheic dermatitis, mycosis fungoides pruritus symptomatic .It is also used for the treatment of insect bites, parasitic prurigo through specific treatment. It has a good effect on the treatment of psoriasis .
Adverse reactions	1. There are a small number of patients whose applicator parts of the skin occurs burning, stinging, itching temporary, long-term use can occur telangiectasia skin (especially face), skin atrophy, stretch marks (teenagers prone), fragile skin, hirsutism, folliculitis, milia, skin bleaching, delayed ulcer healing, packet method in skin folds easily causes fungal infection. 2. When it is much absorbed through the skin, it can cause systemic adverse reactions.
Contraindications	1.Patients who are allergic to this drug and adrenal corticosteroids are banned. 2. The primary skin diseases , exudative dermatitis, ulcerative lesions, acne, rosacea caused by bacteria, fungi, viruses and parasites are banned. 3. It is forbidden using in the eyelid portion (cause a risk of glaucoma).
Precautions	1. The large area of large quantities of drugs or medication packet mode allow more amount of the drug being absorbed through the skin, which causes systemic reactions, especially in young children and infants, it can cause reversible Cushing's syndrome and growth retardation, sudden withdrawal can cause acute adrenal insufficiency. 2. When the local intolerance phenomena occurs,the drug should be stopped and the reason should be found. 3. It should be paid attention that drug staying in the skin folds and diaper can be absorbed into the body.
Specification	Ointments, creams, solutions: 0.1%.
Application	Cortical hormone drugs for the treatment of psoriasis and eczema dermatitis .
Usage	Anti-inflammatory (topical).

Halcinonide Preparation Products And Raw materials

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