Details:

Prilocaine Basic information

Product Name:	Prilocaine
Synonyms:	2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512
CAS:	721-50-6
MF:	C13H20N2O
MW:	220.31
EINECS:	211-957-0
Product Categories:	Active Pharmaceutical Ingredients;Inhibitors
Mol File:	721-50-6.mol

Prilocaine Usage And Synthesis

Local anesthetic drug	Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline. [Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6 ~ 7min and the duration time of about 1.5 ~ 2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta. [Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring. [Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia. [Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours. Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours. Epidural anesthesia: use10 to 30 mL of 1.5% ~ 1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg. Figure 1 the structural formula of prilocaine The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties	It is a kind of needle-like crystals with the melting point being 37-38 ℃ and the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless.
Application	It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.
Production method	O-toluidine and α- bromo-propionyl bromide are condensed and further have reaction with propylamine obtain prilocaine.

Company Information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material . 

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others. These products have been being well exported to europe, southeast Asia, the Middle East ,Africa, South America and some other countries and areas. 

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team. We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market. 

We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!