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1 Kilogram |
Negotiable |
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate 52-01-7 17-alpha-Pregn-4-ene-21-carboxylic acid,
17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate Chemical Properties |
mp | 207-208 °C(lit.) |
alpha | -37 º (c=1, CHCl3) |
refractive index | -36 ° (C=1, CHCl3) |
storage temp. | Store at RT |
Water Solubility | practically insoluble |
Merck | 8760 |
CAS DataBase Reference | 52-01-7(CAS DataBase Reference) |
NIST Chemistry Reference | Spironolactone(52-01-7) |
EPA Substance Registry System | Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy- 3-oxo-, .gamma.-lactone, (7.alpha.,17.alpha.)-(52-01-7) |
Safety Information |
Hazard Codes | T,Xn,Xi |
Risk Statements | 60-40-36/37/38 |
Safety Statements | 53-22-36/37/39-45-36-26 |
WGK Germany | 3 |
RTECS | TU4725000 |
Hazardous Substances Data | 52-01-7(Hazardous Substances Data) |
Category | toxic substances |
Toxicity grading | highly toxic |
Acute toxicity | intraperitoneal - rat LD50: 277 mg / kg; intraperitoneal port - Mouse LD50: 260 mg / kg |
Flammability and hazardous characteristics | easily flammable with combustion generating toxic fumes of sulfur oxides |
Storage characteristics | Treasury: ventilation, low-temperature and dry; store it separately from food raw materials |
Extinguishing agent | Dry powder foam, sand, carbon dioxide, spray water |
Chemical Properties | White to Off White Solid |
Usage | It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia |
Usage | diuretic, aldosterone antagonist |
Biological Activity | Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis. |
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