Estriol cas 50-27-1...

Estriol cas 50-27-1.1

Estriol cas 50-27-1.1

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10 Gram

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  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,Other

Keywords

Estriol cas 50-27-1 TRIDESTRIN

Quick Details

  • Appearance:white crystalline powder
  • Application:A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol
  • PackAge:in foil bag or customized
  • ProductionCapacity:10|Kilogram|Week
  • Storage:It should be sealed upon shading for storage.
  • Transportation:

Superiority:

Estriol Chemical Properties
mp  280-282 °C(lit.)
refractive index  58 ° (C=0.4, Dioxane)
storage temp.  -20°C Freezer
Merck  3707
CAS DataBase Reference 50-27-1(CAS DataBase Reference)
NIST Chemistry Reference Estriol(50-27-1)

 

Details:

Estriol Usage And Synthesis
Natural hormone Estriol belongs to natural hormone and is the metabolite of estradiol in vivo. It is mainly presented in the urine. Estrogen has a relative small activity with the oral activity being 6 times as high as estrone but being weaker than estradiol with non-carcinogenic effects. 
the formula of estriol
Figure 1 is the formula of estriol
Pharmacokinetics It can be absorbed from the gastrointestinal tract and skin but is susceptible to damage upon oral administration and is therefore mainly subject to intramuscular injection and topical usage. It is metabolized in the body to less-active estrone and estriol and can be inactivated when being combined with glucuronic acid and sulfuric acid and further excreted in urine.
Storage It should be sealed upon shading for storage.
Chemical Properties It is white crystalline powder with the M.p. being 283 ℃, relative density being 1.27, and the specific rotation being [α] 25D + 34.4°(pyridine) and 25D + 58°± 5°(4%, dioxane). Its ethanol solution has maximum absorption at the wavelength of 280 nm. The crystal is insoluble in water, slightly soluble in ethanol (1: 500), diethyl ether, chloroform, dioxane and vegetable oil and easily soluble in pyridine and alkali hydroxide solution.
Application It belongs to estrogen drug. It can be used for treating leukopenia, various kinds of menopathy, senile vaginitis, and menopausal syndrome. You may also get temporary breast swelling and lumps, menstrual cycle disorders with self-recovery after stopping the drug for about 1 month. Patients of breast hyperplasia, breast lumps, and cancer potentially being related to female hormone-related cancer, aplastic anemia and liver disease patients should be disabled.
Production method Take estrone as raw material; go through acetylation, epoxidation, and reduction to obtain the estriol products. 
Estrone [acetylation] → [16, 17- epoxidation] → [rearrangement] → [Restore] → [hydrolysis] → finished product of estriol. 
Estrone acetate successively goes through followed enolization, acetylation, epoxidation and reduction to obtain it.
Chemical Properties White Crystalline Powder
Usage 17b-estradiol metabolite, primary estrogen in urine
Usage A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol

 

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