Adenosine 58-61-7

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,

Keywords

Adenosine 58-61-7 D-ADENOSINE

Quick Details

Appearance:white crystalline powder
Application:antiarrhythmic, cardiac depressant
PackAge:in foil bag or customized
ProductionCapacity:10|Metric Ton|Day
Storage:
Transportation:by sea or by air

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Details:

Adenosine Chemical Properties

mp	234-236 °C(lit.)
storage temp.	2-8°C
Merck	14,153
BRN	93029
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	58-61-7(CAS DataBase Reference)
NIST Chemistry Reference	adenosine(58-61-7)

Safety Information

Safety Statements	24/25
WGK Germany	2
RTECS	AU7175000
F	10-23

MSDS Information

Provider	Language
Adenosine	English
SigmaAldrich	English
ACROS	English
ALFA	English

Adenosine Usage And Synthesis

Physiological function	Adenosine is the active substance with the basic structure of the nucleoside and purine, which is a kind of nucleoside formed by adenine through beta glyosidic bond with D-ribose. It widely exists in all types of cells, which can be in the form of free or with the combination of nucleosides in nucleic acids. Adenosine phosphate, like ATP, is an important energy carrier in biochemical reactions. Adenosine is a natural nucleotide, which is the intermediate product of metabolism, and is also one of the important active components in the body. Its function is realized through the activation of the adenosine receptor (A receptor). Adenosine activates G protein coupled potassium channels by binding to the A receptor which makes increasing the outflow of K+ and cell membrane hyperpolarization so as to decrease the automaticity in the atrium, sinoatrial node and atrioventricular node. It can also significantly increase the level of cGMP , prolong ERP of the atrioventricular node and slowing of atrioventricular, depress sympathetic nervous or early and delayed after depolarization induced by isoproterenol and then plays an effective role in arrhythmia. This product has not been classified in I ~ IV anti arrhythmia medicine. Adenosine is an inhibitory neuromodulator in the central nervous system, which can provide a signal between the brain's energy storage and energy requirements, so as to achieve a balance. Under normal conditions, the extracellular adenosine concentration was maintained at 40 ~ 400nmoL.During ischemia and hypoxia, Glucose and glycogen are accelerated decomposition to produce ATP in response to energy demand; ATP degrade, so that the level of intracellular adenosine increases dramatically, and then is released to the outside of the cells to play its regulatory role. In the recovery phase of hypoxia, endogenous adenosine is the precursor of ATP synthesis, and ATP can be re generated under the action of adenosine kinase (AK) in order to prolong the survival time of the cells. Adenosine has a role in the expansion of coronary artery and myocardial contractility .Clinical application in the treatment of angina, hypertension, cerebrovascular disorders, stroke sequelae, muscular atrophy, etc. Intravenous injection for the treatment of ventricular tachycardia and 201Tl myocardial imaging. The above information is edited by the chemicalbook of Tian Ye.
Vidarabine	Vidarabine is a kind of artificial synthetic antitumor compounds, which belongs to adenosine derivatives, extracted from actinomyces fermentation liquid, with a broad spectrum of anti-herpes virus and anti-hepadna virus effect .After entering the infected cells it generates a biologically active triphosphate vidarabine. Interfering with viral DNA synthesis for broad-spectrum antiviral.It can be quickly into the cells through intravenous administration and the concentration of kidney, liver, spleen is high; the concentration in cerebrospinal fluid is 1/3 of blood concentration. The product has an significant inhibitory effect on herpes virus, adenovirus, chicken pox virus, hepatitis B virus and so on, but the RNA virus is invalid. Compared with similar products idoxuridine, vidarabine is more effective on deep infection of DNA viruses or recurrent infection, which has lower toxicity and weaker effect than Arabinoside. Vidarabine has broad-spectrum anti-viral DNA effects in tissue culture to suppress herpes simplex virus Ⅰ, Ⅱ type, chicken pox----Zoster virus, cytomegalovirus, E-B virus, pox virus, and pseudorabies virus. Triphosphate adenosine can inhibit herpes simplex and hepatitis B virus DNA polymerase. It has no cross resistance with other types of anti-herpes drugs. Animal experiments show that it has effective for the herpes simplex virus keratitis and the herpes simplex virus and the pox virus encephalitis in rabbits, but the effect on the infection of guinea pig skin herpes virus is bad, and it is effective for chimpanzee and human hepatitis B virus infection. Adenosine has less toxicity, but large dose has teratogenic and mutagenic side effects. Vidarabine mechanism has not been fully elucidated, mainly phosphorylated to vidarabine triphosphate in intracellular, inhibited viral DNA polymerase, whose inhibition of DNA polymerase is weak, thus selectively inhibit the synthesis and replication of viral DNA.
Chemical Properties	Crystallization from water, Melting point: 234--235℃. [α]D11-61.7°(C=0.706,water);[α] D9-58.2°(C=0.658，water).Insoluble in alcohol.
Application	Anti-arrhythmia drugs, it can make paroxysmal ventricular tachycardia into sinus rhythm. Used for ventricular arrhythmias associated with atrioventricular. Antiviral drugs. In the pharmaceutical industry, it is mainly used for the manufacture of the main raw materials of the drugs, such as adenosine triphosphate, coenzyme and its series products such as cyclic adenosine monophosphate and so on. For the manufacture of ATP, adenosine, coenzyme A, etc. Treatment of angina pectoris, myocardial infarction, coronary insufficiency, atherosclerosis, hypertension, cerebrovascular disease, stroke sequelae, progressive muscular atrophy. Atrioventricular block and acute myocardial infarction patients disabled.
Category	Toxic Substances
Toxicity grading	Moderately toxic
Acute toxicity	Peritoneal - mouse LD50: 500 mg / kg
Flammability hazard characteristics	Combustible; combustion releases toxic nitrogen oxide smoke.
Storage and transportation characteristics	Treasury ventilation low-temperature drying; and food raw materials stored separately.
Extinguishing agent	Dry powder, foam, sand, carbon dioxide, water mist.
Chemical Properties	White crystalline powder
Usage	antiarrhythmic, cardiac depressant
Usage	Nucleotide.
Biological Activity	Neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes.