Betamethasone378-44...

Betamethasone378-44-9
Betamethasone378-44-9
Betamethasone378-44-9
Betamethasone378-44-9

Betamethasone378-44-9

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : D/A,D/P,T/T

Keywords

Betamethasone 378-44-9 C22H29FO5

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  • Appearance:detailed in specifcations
  • Application:Aripiprazole Intermediate functional food additives
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  • ProductionCapacity:500|Metric Ton|Month
  • Storage:Keep in dry and cool condition
  • Transportation:by air or sea

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Company information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

Details:

Product Name: Betamethasone
Synonyms: (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;16-beta-methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20;16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione;17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-9-alpha-fluoro-11-bet;6beta)-;9-alpha-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione;9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-diene;9-alpha-fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20
CAS: 378-44-9
MF: C22H29FO5
MW: 392.46
EINECS: 206-825-4
Product Categories: Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Pharmaceutical intermediate;CELESTONE
Mol File: 378-44-9.mol
Betamethasone Structure
 
Betamethasone Chemical Properties
mp  235-237°C
refractive index  118 ° (C=1, Dioxane)
storage temp.  0-6°C
Merck  1180
CAS DataBase Reference 378-44-9(CAS DataBase Reference)
NIST Chemistry Reference Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9)
 
Safety Information
Hazard Codes  Xi,Xn,T
Risk Statements  40-48/20/21-61
Safety Statements  22-36-45-53
RTECS  TU4000000
HS Code  29379000
Hazardous Substances Data 378-44-9(Hazardous Substances Data)
MSDS Information
 
 
Betamethasone Usage And Synthesis
hormone drugs Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone .
Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension.
Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections.
The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on.
The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless.
Application Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.
production method According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol - chloroform - water mixture , it can be converted to betamethasone.
Category Toxic substances
Toxicity grading Middle toxic
Acute toxicity Oral -mouse LD50:> 4500 mg / kg
Flammability and hazard characteristics Combustible

 

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