Fasudil hydrochlori...

Fasudil hydrochloride   105628-07-7   C14H18ClN3O2S
Fasudil hydrochloride   105628-07-7   C14H18ClN3O2S
Fasudil hydrochloride   105628-07-7   C14H18ClN3O2S
Fasudil hydrochloride   105628-07-7   C14H18ClN3O2S

Fasudil hydrochloride 105628-07-7 C14H18ClN3O2S

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Fasudil hydrochloride 105628-07-7 C14H18ClN3O2S

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  • Appearance:detailed in specifcations
  • Application:Aripiprazole Intermediate functional food additives
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  • ProductionCapacity:500|Metric Ton|Month
  • Storage:Keep in dry and cool condition
  • Transportation:by air or sea

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Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

Details:

Fasudil hydrochloride Basic information
Outline Pharmacological effects Application
Product Name: Fasudil hydrochloride
Synonyms: 1-(5-ISOQUINOLINYLSULFONYL)HOMOPIPERAZINE DIHYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, DIHYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE 2HCL;1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE DIHYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE HCL;1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL;5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE
CAS: 105628-07-7
MF: C14H18ClN3O2S
MW: 327.83
EINECS:  
Product Categories: APIs;API;Inhibitor;Cardiovascular & Blood System Agents;Inhibitors
Mol File: 105628-07-7.mol
Fasudil hydrochloride Structure
 
Fasudil hydrochloride Chemical Properties
solubility  H2O: >200 mg/mL
form  solid
color  white
CAS DataBase Reference 105628-07-7(CAS DataBase Reference)
 
Safety Information
WGK Germany  3
RTECS  HM4031166
MSDS Information
Provider Language
SigmaAldrich English
 
Fasudil hydrochloride Usage And Synthesis
Outline Fasudil hydrochloride is a novel drug having a wide range of pharmacological effects ,it is first developed by Asahi Kasei Corporation, in June 1995 it was listed for the first time in Japan. It is Ratified by China in 2001,that Asahi Kasei Corporation imports fasudil hydrochloride injection under the trade name " Eril." Its molecular structure is 5-isoquinoline sulfonamide derivative,it is RHO kinase inhibitor, by increasing the myosin light chain phosphatase activity it can dilate blood vessels, reduce the tension of endothelial cells, improve brain microcirculation, and does not produce and aggravate Pirates of the brain blood, and it can antagonize inflammatory cytokines, anti-apoptotic neuroprotective, and promote nerve regeneration. Fasudil hydrochloride has a certain effect on promoting the recovery of nerve function, reducing symptoms and reducing morbidity . at the grassroots level due to the constraints of economic conditions and the level of awareness of the disease, ultra-early thrombolytic therapy can not be achieved, but in order to reduce further progression of the disease within the therapeutic window of time, to rebuild local blood circulation is critical, and Fasudil hydrochloride has significant neuroprotective and therapeutic effects on ischemic cerebrovascular disease, it is worth in clinical use, especially at the grassroots level, to reduce morbidity and improve quality of life.
Pharmacological effects Fasudil hydrochloride is an isoquinoline sulfonamide derivative which can not only inhibit the intracellular calcium ion activity, but also inhibit protein kinase AGC and myosin light chain kinase, which means inhibiting smooth muscle contraction, myosin light chain phosphorylation in the final stage , relaxes vascular smooth muscle, dilates blood vessels. In vitro experiments show that the product can make cerebrovasculara In vitro relax, and it can inhibit the contraction of blood vessels in vitro caused by calcium

 

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