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703-95-7 703-95-7 703-95-7
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HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
Details:
| 5-Fluoroorotic acid Basic information |
| Product Name: | 5-Fluoroorotic acid |
| Synonyms: | 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci;1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid;5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci;5-fluoroorotate;5-fluoro-oroticaci;ent-26398;fluorooroticacid;fo |
| CAS: | 703-95-7 |
| MF: | C5H3FN2O4 |
| MW: | 174.09 |
| EINECS: | 211-876-0 |
| Product Categories: | Aromatic Halides (substituted);Nucleotides and Nucleosides;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;5-FOA;Bases & Related Reagents;Nucleotides;pyrimidine;Fluorine series |
| Mol File: | 703-95-7.mol |
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| 5-Fluoroorotic acid Chemical Properties |
| mp | 278 °C (dec.)(lit.) |
| storage temp. | −20°C |
| solubility | NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
| Merck | 4176 |
| CAS DataBase Reference | 703-95-7(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36-36/37/39-27 |
| WGK Germany | 3 |
| RTECS | UV7800000 |
| F | 10 |
| Hazard Note | Irritant |
| HazardClass | IRRITANT |
| MSDS Information |
| Provider | Language |
|---|---|
| 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid | English |
| 5-Fluoroorotic acid Usage And Synthesis |
| Chemical Properties | White to Off-White Crystalline Solid |
| Usage | 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents. |
HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
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