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HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
Details:
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5-Fluoroorotic acid Basic information |
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Product Name: |
5-Fluoroorotic acid |
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Synonyms: |
1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci;1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid;5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci;5-fluoroorotate;5-fluoro-oroticaci;ent-26398;fluorooroticacid;fo |
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CAS: |
703-95-7 |
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MF: |
C5H3FN2O4 |
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MW: |
174.09 |
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EINECS: |
211-876-0 |
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Product Categories: |
Aromatic Halides (substituted);Nucleotides and Nucleosides;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;5-FOA;Bases & Related Reagents;Nucleotides;pyrimidine;Fluorine series |
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Mol File: |
703-95-7.mol |
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5-Fluoroorotic acid Chemical Properties |
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mp |
278 °C (dec.)(lit.) |
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storage temp. |
−20°C |
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solubility |
NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
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Merck |
4176 |
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CAS DataBase Reference |
703-95-7(CAS DataBase Reference) |
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5-Fluoroorotic acid Usage And Synthesis |
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Chemical Properties |
White to Off-White Crystalline Solid |
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Usage |
5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
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(R)-(-)-4-Phenyl-2-oxazolidinone Basic information |
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(R)-(-)-4-Phenyl-2-oxazolidinone Chemical Properties |
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mp |
131-133 °C(lit.) |
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alpha |
-49.5 º (c=2, CHCl3) |
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refractive index |
-72 ° (C=1, AcOEt) |
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storage temp. |
Store at 0-5°C |
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Stability: |
N/A |
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CAS DataBase Reference |
90319-52-1(CAS DataBase Reference) |
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(R)-(-)-4-Phenyl-2-oxazolidinone Usage And Synthesis |
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Chemical Properties |
white to light yellow crystal powde |
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Usage |
synthon for a-amino acids and b-lactam antibiotics |
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HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.