Capsaicin 404-86-4,chemical research,C18H27NO3
Capsaicin Chemical Properties |
mp | 62-65 °C(lit.) |
bp | 210-220 C |
FEMA | 3404 |
Fp | 113 °C |
storage temp. | 2-8°C |
solubility | H2O: insoluble |
Water Solubility | insoluble |
Merck | 1768 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 404-86-4(CAS DataBase Reference) |
EPA Substance Registry System | 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-, (6E)-(404-86-4) |
Safety Information |
Hazard Codes | T,T+ |
Risk Statements | 25-37/38-41-42/43-36/37/38 |
Safety Statements | 22-26-28-36/39-45-36/37/39 |
RIDADR | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | RA8530000 |
F | 10-21 |
HazardClass | 6.1(a) |
PackingGroup | II |
Hazardous Substances Data | 404-86-4(Hazardous Substances Data) |
Capsaicin Usage And Synthesis |
Chemical Properties | Off-White Crystalline Solid |
Usage | A representative lot is a 5:1 E:Z mixture. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. |
Usage | K channel blocker; multiple sclerosis therapy |
Usage | analgesic (topical), depletes Substance P, neurotoxic |
Usage | Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic. |
Usage | Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin). |
Biological Activity | Prototypic vanilloid receptor agonist (pEC 50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ . |
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