7-Ethyl-10-hydroxyc...

7-Ethyl-10-hydroxycamptothecin  86639-52-3
7-Ethyl-10-hydroxycamptothecin  86639-52-3
7-Ethyl-10-hydroxycamptothecin  86639-52-3
7-Ethyl-10-hydroxycamptothecin  86639-52-3

7-Ethyl-10-hydroxycamptothecin 86639-52-3

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : D/A,D/P,T/T

Keywords

7-Ethyl-10-hydroxycamptothecin 86639-52-3 C22H20N2O5

Quick Details

  • Appearance:detailed in specifcations
  • Application:Aripiprazole Intermediate functional food additives
  • PackAge:as needed
  • ProductionCapacity:500|Metric Ton|Month
  • Storage:Keep in dry and cool condition
  • Transportation:by air or sea

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Company information

Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.

Details:

7-Ethyl-10-hydroxycamptothecin Basic information
Product Name: 7-Ethyl-10-hydroxycamptothecin
Synonyms: CAMPTOTHECIN, 7-ETHYL-10-HYDROXY;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-ETHYL-10-HYDROXYCAMPTOTHECIN;7-ETHYL-10-HYDROXYCAMPTOTHECINE;7-ETHYL-10-HYDROXY-CPT;SN38;10-dihydroxy-;4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3
CAS: 86639-52-3
MF: C22H20N2O5
MW: 392.4
EINECS:  
Product Categories: Pharmaceutical Raw Materials;Miscellaneous Natural Products;Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Inhibitors
Mol File: 86639-52-3.mol
7-Ethyl-10-hydroxycamptothecin Structure
 
7-Ethyl-10-hydroxycamptothecin Chemical Properties
mp  217 °C
refractive index  21.5 ° (C=0.2, THF)
storage temp.  −20°C
CAS DataBase Reference 86639-52-3(CAS DataBase Reference)
 
Safety Information
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RTECS  UQ0491000
MSDS Information
 
 
7-Ethyl-10-hydroxycamptothecin Usage And Synthesis
Chemical Properties Light-Yellow Solid
Usage A metabolite of Irinotecan, a DNA topoisomerase inhibitor
Biological Activity Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
 
7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials
Preparation Products Irinotecan

 

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