Disodium phosphonomycin

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 98%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Disodium phosphonomycin 26016-99-9 manufacturer , better price with good quality

Quick Details

Appearance:White Solid
Application:Pharmaceuticals
PackAge:Depended
ProductionCapacity:300|Kilogram|Month
Storage:KEEP COLD
Transportation: BY SEA OR AIR

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Disodium phosphonomycin Basic information

Appearance Properties Pharmacological effects Indications Usage and dosage Combination therapy Detection Indicator Precautions Application

Product Name:	Disodium phosphonomycin
Synonyms:	(1,2-epoxypropyl)-,disodiumsalt(1r,2s)(-)-phosphonicaci;(2r-cis)-(3-methyloxiranyl)phosphonicaciddisodiumsalt;(3-methyloxiranyl)-,disodiumsalt,(2r-cis)-phosphonicaci;disodiumfosfomycin;fom-na;fosfomycindisodium;fosfomycinsodiumsalt;phosphonomycinsodium
CAS:	26016-99-9
MF:	C3H5Na2O4P
MW:	182.02
EINECS:	247-409-2
Product Categories:	chiral;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;Peptide Synthesis/Antibiotics;API;antibiotic;Antibiotics
Mol File:	26016-99-9.mol

Disodium phosphonomycin Chemical Properties

mp	>300°C
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
CAS DataBase Reference	26016-99-9(CAS DataBase Reference)

Safety Information

Hazard Codes	F,C
Risk Statements	11-34
Safety Statements	16-26-36/37/39-45
WGK Germany	2
RTECS	SZ7902000
F	10-21

MSDS Information

Provider	Language
SigmaAldrich	English

Disodium phosphonomycin Usage And Synthesis

Appearance Properties	It appears as a white crystalline powder at room temperature, hygroscopic, easily soluble in water, heated while dissolving. Fosfomycin Sodium can combine with a bacterial cell wall synthesis enzyme, hinder bacterial cell wall synthesis related substances utilizing at the first reaction, which in turn has a bactericidal effect. have antibacterial effect for Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Proteus mirabilis, Salmonella typhi, Serratia bacteria, most Pseudomonas aeruginosa, Streptococcus pyogenes, Streptococcus faecalis, part indole-positive Proteus and certain Klebsiella, Enterobacter bacteria. The main clinical applications of Fosfomycin Sodium include: urinary tract treatment of sensitive Gram-negative bacteria caused urinary system, infection of skin and soft tissue, respiratory, intestinal and other parts. It can also be combined with other antibiotics, the treatment of severe infections caused by susceptible strains such as sepsis, pulmonary, meningeal infections, peritonitis, adnexitis, intrauterine infections, pelvic inflammatory disease, osteomyelitis. Also in combination with vancomycin for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection.
Pharmacological effects	1. Broad spectrum antibiotic, high bioavailability, rapid absorption, strong anti-bacterial, not diet affected. Fosfomycin Sodium displays effects on killing Gram-positive and Gram-negative bacteria, especially Pseudomonas aeruginosa, Proteus, Salmonella, and exhibit excellent antibacterial activity for a variety of drug-resistant Staphylococcus aureus and Escherichia coli. For usage in animals, there is no drug resistance and cross-resistance. Clinical effect is good. 2. Rapid sterilization: This product is a rapid fungicide, its role is still evident after 1-2 hours. About 25% of the E. coli were killed at 1 hour after exposured to Fosfomycin Sodium (12.5μg / ml), and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also all killed at 4 and 8 hours. 3. Low toxicity, little irritation on the body, no acute toxicity and adverse reactions, no increased burden on the kidney. 4. Low residue: the eliminate time for the muscles and organs to reach the residual standard is 48-72 hours. The above information is edited by the Chemicalbook of Tian Ye.
Indications	Mainly used for Staphylococcus aureus, streptococcus, E. coli, Salmonella and other gram-negative bacteria caused acute and chronic bowel disease treatment in chickens, ducks, pigs.
Usage and dosage	Used in water for livestock and poultry: every 100kg of water added the product 5-10 grams, 2 times a day, once every three days. Used in animal spices: 10-15 g of the product added to per 100kg feed, 2 times a day, once every three days.
Combination therapy	For the treatment of intestinal infections, Fosfomycin Sodium can combine with β- lactam, aminoglycoside. For the treatment of respiratory and lung infections, combining with macrolides, β- lactam. For staph infections, better combined with erythromycin, rifampin. For the treatment of acute respiratory infections, sepsis, peritonitis ect., increase the dose. Need to combine with β- lactams or aminoglycosides.
Detection Indicator	No. Test item Export standard CP2000 Edition 1 Traits: A white crystalline powder, odorless, taste salty white crystalline powder, odorless, salty taste 2 Discriminator: Positive reaction Positive reaction 3 Specific rotation ° -4.2 ~ -5.5 -4.2 ~ -5.5 4 Heavy Metal ≤0.0010% 0≤.0010% 5 Content ≥700μ / mg ≥700μ / mg 6 Alkalinity 9.0-10.5 9.0-10.5 7 Weight loss on drying ≤1.0% ≤1.5% (water) 8 Solution clarity ≤No. 3 / 4 turbidity standards solution ≤No. 1 turbidity standard solution 9 Color of the solution ≤Yellow No. 1 ≤ Yellow No. 1 10 Glycols ≤0.50% ≤0.50% 11 Clarity of solution: can not be detected, in compliance with (a gross point ≤8 / g, wherein a color point ≤2 / g) 12 W ≤0.002% - 13 phosphorus content - 16.2-17.9% 14 Sterile: Subject to compliance 15 Heat source/ bacterial endotoxin: compliance (heat source) compliance (bacterial endotoxin) 16 α- phenylethylamine ≤0.01% - 17 Residual amount of methanol: real 18 Residual amount of ethanol: Real The above information is the main export detection index of fosfomycin.
Precautions	1. This product is mainly used for pigs, chickens, fish; application for other animals should medication under veterinary guidance. 2. Fosfomycin Sodiumand β- lactams, aminoglycosides, macrocyclic acid esters have a synergistic effect of combination therapy, and can reduce or delay the occurrence of bacterial resistance.
Application	For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella.
Chemical Properties	White Solid
Usage	Curariform muscle relaxants
Usage	Antibiotic

Disodium phosphonomycin Preparation Products And Raw materials

Details:

Henan Sunlake Enterprise Corporation is located in Henan Province, the central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . These products have been being well exported to Europe , Southeast Asia , the Middle East , Africa , South America and some other countries and areas.

We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.

We are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,Which finally makes us being a reliable and professional supplier in international market.

We welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Our Advantages:

I). We have abundant professional production experience.

II). We have our own chemical factory.

III). Sample is free of charge.

IV). Reasonable Price, Excellent Quality & Attentive Service

V). Prompt reply: we can reply your inquiry and email within 24 hours.

VI). Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.

VII). We have passed the LFGB, SGS, STC, HSL and some other tests.

VIII). We have a unity cooperation team.

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